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Immune Cells Exploit a Neural Circuit to Enter the CNS

Discussion in 'Other Health News and Research' started by lansbergen, Jan 10, 2013.

  1. lansbergen

    lansbergen Senior Member

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    http://211.144.68.84:9998/91keshi/Public/File/42/148-3/pdf/1-s2.0-S0092867412000918-main.pdf

    Kevin J. Tracey1,*

    1Laboratory of Biomedical Science, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA

    DOI 10.1016/j.cell.2012.01.025

    Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central
    nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at
    a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit
    originating from leg muscle contractions.
     
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