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Immune Boosting Effects of B3/Niacin.

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Ema, Oct 11, 2013.

  1. Ema

    Ema Senior Member

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    Buhner talks about niacin in his Lyme protocol as well.
    I think it is super interesting because my neutrophils are consistently below range. It would be awesome if something like this would really work! At least it is unlikely to cause harm.
    Niacin may also help with migraines...which would be great too!
    Ema
    From: naturalnews.com

    Originally published September 4 2012
    Vitamin B3 may be the cure for drug-resistant superbug infections

    by Ethan A. Huff, staff writer

    (NaturalNews) While the pharmaceutical industry is busy trying to conjure up new drugs to tackle the antibiotic-resistant "superbug" epidemic, a recent study published in the Journal of Clinical Investigationexplains how simple vitamin B3, also known as nicotinamide (NAM), taken in high doses may effectively thwart staph and other potentially life-threatening infections without the need for drugs.

    Researchers from both Cedars-Sinai Medical Center in California and the Linus Pauling Institute (LPI) at Oregon State University (OSU) collaborated with one another to test the effects of high doses of NAM administered to both live mice and human blood infected with Staphylococcus aureus (S. aureus). What they found was that vitamin B3 significantly boosts the number and effectiveness of neutrophils, or white blood cells that target infections.

    It turns out that, when taken in doses far higher than those recommended by the federal government, vitamin B3 is capable of significantly boosting the body's own natural immune system to the point where many diseases simply cannot survive. According to the study, vitamin B3 is capable of increasing immune capacity by 1,000 times, allowing the body to naturally fight MRSA and other deadly pathogens.

    "This could give us a new way to treat staph infections that can be deadly," said Adrian Gombart, an associate professor at LPI, about the dramatic findings. "It's a way to tap into the power of the innate immune system and stimulate it to provide a more powerful and natural immune response."

    NAM is not just effective against S. aureus, though. Several other virulent pathogens, including human immunodeficiency virus (HIV), also seem to respond favorably to NAM's dramatic immune-boosting capacity. By bolstering the immune system's natural defenses, NAM appears to facilitate the destruction and elimination of a host of deadly pathogens and viruses.

    "NAM is not only effective against S. aureus, it also has demonstrated efficacy against other major human pathogens, such as K. pneumoniae (Klebsiella pneumoniae) and P. aeruginosa (Pseudomonas aeruginosa), in our human peripheral blood killing assay," wrote the authors in their discussion. "We have demonstrated that NAM, as an HDAC inhibitor, can improve host defense and thereby promote bacterial clearance."

    And unlike antibiotic drugs, vitamin B3 does not destroy all the beneficial bacteria in the gut along with the harmful bacteria. So for most people, taking mega-doses of therapeutic vitamin B3 is preferable to taking immune-destroying antibiotics that can later promote the growth of Candida albicans and other harmful yeast overgrowths and bacterial imbalances within the body.

    Sources for this article include:

    http://www.jci.org/articles/view/62070?key=a39ce7efc2f764ede04

    http://www.feedstuffs.com

    http://www.foxnews.com
     
  2. Ema

    Ema Senior Member

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    http://www.mpg.de/1076587/Nicotine_Immune_Cells_Artherosclerosis


     
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  3. shannah

    shannah Senior Member

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    I can't locate the amount used. Anyone?
     
  4. Ema

    Ema Senior Member

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    I think they are high - 80-90 mg/kg if I recall correctly.

    The doses I saw for anxiety and depression also go along with that - 1000-3000 mg three times a day.

    I wonder if there are any risks to taking that much?
     
    shannah likes this.
  5. rosie26

    rosie26 Senior Member

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    I had a quick look on google an hour ago and their are toxic doses, where you can get liver damage and can cause I think Diabetes 2.
     
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  6. Ema

    Ema Senior Member

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    All these forms of niacin are terribly confusing to me so please don't take this as authority...from what I have read >1000 mg of sustained release niacin can cause liver damage. Doses greater than 3000 mg of the flushing form are considered to be toxic by some. But then you see people taking up to 9000 mg/day without issue.

    So I really have no idea! Hopefully someone more familiar with niacin will see this thread and comment.

    I get liver labs every 2 weeks for the cidofovir anyway so I'll see pretty quickly if it becomes an issue.
     
  7. Abha

    Abha Abha

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    Hi Emma/all,
    I have taken 1ooomgx3(day)(for 4 months) plus an extract(Berberin/grapewood?) to help with my own health problems.I heard about the importance of B vitamins in early 1980's directly from Dr Kenneth Mc All.At that time he prescribed large doses of B1,B3 and B6 for my problems.More recently I have taken the fore mentioned amounts to help with ongoing health problems.Dr Mercola speaks to some one in his interviews(youtube) re insulin resistance and the importance of B3.It is a lengthy interview and Dr Wright(USA?) is mentioned re B3.He is an expert on that protocol.It is also used to treat arthritis and other problems.If you have liver problems then it is not for you.I have used it for 4 months recently and I have had no problems.I haven't seen any great benefits but who knows it may have helped!There are other doctors(youtube) who speak about B3 and its benefits(like a miracle cure!)
     
  8. Abha

    Abha Abha

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    Hi Emma/All,
    Further to earlier posting..I should have mentioned I used niacinamide.
    In the Youtube video Dr Mercola interviews Dr Dietrich Klinghardt about Lyme disease.After about 1 hr and 2mins they discuss Niacin/niacinamide in relation to Insulin resistance/Lyme disease/and other diseases(osteoarthritis etc).Dr Klinghardt states that niacin and niacinamide have the same antimicrobial activity.You can listen to that yourself by going direct to the point 1 hr 2 mins of the video.Then listen for the next 10 mins or so.Hopefully this has made it clearer!
     
    Ema likes this.
  9. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Ema. Have u come across any info on non flushing niacin, inositol hexaniacinate being effective at increasing neutrophils? ? Higher doses are alot easier to tolerate?

    I have some on hand I used awhile ago now for cholesterol for which it didnt really help. Wish I could remember when I used it tocompare it to past neutrneutrophil tests. Used it well before valcyte.
     
  10. Ema

    Ema Senior Member

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    Niacinamide is the non-flushing part of niacin. That is what I'm using.

    I'm not sure about inositol hexaniacinate...the studies seem to reference niacinamide most often.

    I'm getting blood work tomorrow so we'll see if the niacinamide has done anything for my neutrophils...
     
    Last edited: Nov 26, 2013
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  11. knackers323

    knackers323 Senior Member

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    Anyone seen the immune boosting effects of b3 in action?
     
  12. Changexpert

    Changexpert

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    I was diagnosed with very low neutrophils and WBC counts back in November. I got so sick in December to the point I had severe digestive issues. Upon researching potential supplements for immune boost, I decided to try Lactoferrin. To my surprise, lactoferrin worked very well and my WBC level went from 3,000/uL to 4,800/uL in just one month! Neutrophil increased from 900/uL to 2,800/uL as well, and the percentage went from 29% to 53%. One side effect I had with lactoferrin was increased hair loss, which I am still not sure why that occurred.

    Even though lactoferrin is great at boosting immune system, there is no consensus on how that is achieved and what kind of impact it has on the overall immune response. Some studies say lactoferrin acts as an adaptogen, correcting imbalance between th1 and th2. Some studies say it shifts body toward th1 while others say toward th2. This particular study shows the shift toward th2, which is not where we want to be. http://www.ncbi.nlm.nih.gov/pubmed/8874770

    My advice on lactoferrin would be to use it for one week, see how your body reacts, and prolong no more than one month. Once your body's immune system's blood work is in the reference range, it can start working again to head toward right direction.
     
  13. Gondwanaland

    Gondwanaland Senior Member

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    I had increased WBC and RBC count by taking 1g glutamine daily for 1 week. Haven't tried B3 on its own yet.
     

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