The Power and Pitfalls of Omics: George Davey Smith’s storming talk at ME/CFS conference
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Imipramine and Paroxetine

Discussion in 'General Treatment' started by Beyond, Jan 9, 2014.

  1. Beyond

    Beyond Juice Me Up, Scotty!!!

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    How bad are these? My parents are finally firm in the allopathy and the GP prescribed me these. I tried to convince him that I would only take Imipramine but he couldn´t listen to me. I am especially wary of the SSRI. It seems I´ll have to take them at least for 15 days. My hypericum extract is almost here but they say no. I wanted to try that first... I don´t know what I will do. I have read many testimonies against paroxetine in the net.
     
  2. adreno

    adreno Learned helplessness

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    Imipramine probably isn't that bad in small doses, say 10mg. Paroxetine is a pretty horrible SSRI though, others are better. What's the prescription for? Depression? Anxiety? Fatigue?
     
  3. Sidereal

    Sidereal Senior Member

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    Paroxetine tends to be the least tolerated SSRI. It has a very short half life so very difficult to discontinue. Can be very effective for OCD though.
     
  4. Kina

    Kina Moderation Team Lead

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    I was prescribed Imipramine ages ago for sleep -- low doses gave me terrible dry mouth and did nothing for my sleep. That being said, reactions can be quite unpredictable as they vary over individuals.

    I have also read where Paroxetine isn't well tolerated. If you do take it, a slow taper off them when you are finished might be prudent.

    Why are you being prescribed these meds?
     
  5. Hip

    Hip Senior Member

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    I had a terrible reaction to the SSRI citalopram: it created intense suicidal ideation within an hour of taking one pill, and this horrible state lasted for the entire day, until this drug wore off. Suicidal ideation reactions are a known side effect of SSRIs in a small minority of people.

    Interestingly, I had taken citalopram once before, just prior to my ME/CFS, and at that time I did not experience this bad side effect.

    Imipramine used to be my favorite antidepressant for several years, but I did not take this drug on a regular basis. If I felt my depression levels increasing, I would then start taking 10 to 25 mg of imipramine each day for a week or so. But as my depression comes and goes, I tended to stop taking imipramine once I feel better. I found imipramine works quite well when used like this on this temporary basis.

    My favorite antidepressant now is very low dose (12.5 to 25 mg) amisulpride. This drug I find provides such a clean, natural mood boost, that I decided to take it all the time. For me, a clean, natural mood boost is very important. With imipramine, I found that the mood boost does help you overcome depression, but imipramine did not feel entirely natural.

    It is hard to describe what I mean by a "natural" mood boost, but an analogy might be the difference between a true spontaneous smile, which is natural, and a "social smile" that you deliberately put on yourself as a social requirement. To me, the antidepressant effect of very low dose amisulpride feels like a true spontaneous smile, whereas the antidepressant effect of imipramine feels a bit like an artificial social smile. That not a precise analogy, but hopefully it gives you an idea of what I am talking about.

    Spanish saffron 60 mg daily is also a very useful antidepressant with a natural feeling. There are studies showing that saffron has similar antidepressant efficacy to the SSRI Prozac. Saffron works on the serotonin system. I regularly take 60 mg of Spanish saffron stamens daily, along with 12.5 g of amisulpride.
     
    Last edited: Jan 10, 2014
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  6. barbc56

    barbc56 Senior Member

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    If you are uncomfortable with the meds.prescribed, you might want to ask about other AD' options available for pain.
     
  7. Beyond

    Beyond Juice Me Up, Scotty!!!

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    I managed to fight my parents until Paroxetine was out of the question. In fact I am now just taking CLOMIPRAMINE. The doc told me Imipramine but ended prescribing me Tofranil. It is for "OCD". He acts like I have a somatoform disorder, the usual shit, but this time the shit has splattered me, because I am taking this clomipramine (forced) and I feel worse as I was expecting.

    Because of a stupid and dangerous doctor that gets tense when I say "hypothalamic-pituitary-adrenal axis". He says its all an "obsession". My parents are eager to buy that crap.

    @Hip Amisulpride eh? I want to try that. In fact, talking about natural alternatives, I received yesterday two bottles of high quality Hypericum but my parents hid it. Bad timing. I am pushing hard for them to let me try Hypericum and drop these awful drugs. I hate psych drugs.
     
    Last edited: Jan 10, 2014
  8. Hip

    Hip Senior Member

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    @Beyond
    You certainly do seem to be having more than your fair share of problems from family members.

    Note that Tofranil is just a brand name for the drug imipramine.

    This info might be useful:
    It is certainly worth trying these drugs, because you may well find them beneficial. But I can totally understand how you dislike these things being "forced down your throat" by a persuasive doctor/parents. I myself only feel comfortable about trying supplements or drugs under my own terms, in my own timescale, so that I can do the testing carefully and gently.

    I would recommend you keep a diary/journal of your results: in a word processor document, you just need to write down the date and time, the drug/supplement, and the dose taken. Then note any good or bad reactions that you have to that medication in the subsequent days. These notes can be very useful at a later date, as most people with ME/CFS have bad memories, so they may forget what effects a medication has for them.
     
    Last edited: Jan 10, 2014
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  9. Beyond

    Beyond Juice Me Up, Scotty!!!

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    Talking about brain fog, I messed up the name of the drug. It is ANAFRANIL, which is Clomipramine, a close relative of Imipramine.
     
  10. Beyond

    Beyond Juice Me Up, Scotty!!!

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    @Hip doesn´t amisulpride increase prolactin? I have had high prolactin and still have some libido issues. I want to try this med but I wonder if it can decrease my sexual function.

    An interesting quote I found investigating amisulpride:
     
    Last edited: Jan 14, 2014
  11. Hip

    Hip Senior Member

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    @Beyond
    Yes I notice a some decreases in libido from amisulpride, even at the very low dose of 12.5 mg (¼ of a 50 mg tablet) that I am taking. I presume this arises from the increase in prolactin. I find no physical sexual problems from amisulpride; it is just the sexual desire is mentally reduced a little.

    In this thread about the benefits of amisulpride for ME/CFS, Adreno mentions that pantethine (a form of vitamin B5 pantothenic acid) should be an inhibitor of prolactin, so taking pantethine with amisulpride may fix the libido effects.

    I keep meaning to try pantethine with my amisulpride.
     
    Last edited: Jan 15, 2014
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  12. Beyond

    Beyond Juice Me Up, Scotty!!!

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    In fact I am taking pantethine 950 mgs per day and have found a subtle but noticeable improvement in libido and sexual function. This is because I tend to have highish prolactin for some reason. I say subtle because I have taken aphrodisiacs and I use their effects to compare.
     

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