The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Imbalanced Oxidative Stress Causes Chlamydial Persistence during Non-Productive HHV Co-Infection

Discussion in 'Other Health News and Research' started by Dolphin, Oct 19, 2012.

  1. Dolphin

    Dolphin Senior Member

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    Given that the three items in the heading have been mentioned in association with ME/CFS at various times, I thought I'd give this a plug in case it might be of use/interest.

    Free full text: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047427


    * I gave each sentence its own paragraph
     
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  2. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    This is very interesting Dolphin. It might have extensive implications.

    "We are just beginning to understand how the co-evolution of one of the most prevalent human pathogenic bacteria and viruses has affected their survival and replication strategies, but also their infective properties while occupying similar niches inside the cell. The Chlamydia - HHV6 interaction may thus provide a paradigm for a so far unrecognized close interaction of obligate intracellular bacteria and viruses."

    This ties in with both methylation and oxidative and nitrosative stress models of ME, and also shows that, at least potentially, a wide range of pathogen interactions might be able to induce pathogen persistance.

    I have yet to read this paper in detail. Its not light reading but it is very interesting.

    One other implication is that clearance of some of these pathogens, or restoration of antioxidant capacity, might induce improvements with other pathogens.

    Bye, Alex
     
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  3. Timaca

    Timaca Senior Member

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    GOOD FIND!! I have antibody titers as high as the lab measures to HSV1 IgG. I've had a positive IgM. And I've had antibody titers as high as the lab measures to Cpn IgG and IgA. I will certainly show this to my doctors!

    Best, Timaca
     
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