What can I do to try lower it? as a test? I always had issues throughout my life but nothing like this, I had fatigue and focus issues, 4 years ago I tried to treat 'hpa-axis dysfunction/adrenal fatigue' with MEDROL after receiving bad advice and it terrorized my mind (picture constant crying and charging back and forth), coming off of the drug my brain never calmed down. I am 4 years deep into this - I wake up, there is a CHAOS in my mind, a powerful energy/force - constantly overthinking, like my brain is overfiring too much and theres no brakes so it never ends, hopping from topic to topic, deep stressful and obsessive thinking patterns sometimes mixed with a spaceyness but doesnt really feel like adrenaline. Its very hard to explain, it really does not feel like a typical anxiety or stress feeling. I constantly pace up and down. I have tried things such as Alpha Blockers, in high dose. Didnt touch Anxiety whatsoever but it did stop orgasms which tells me the drugs did a good job of blocking adrenaline but adrenaline isnt whats causing my mental struggle. My diet is now filled with vegetables, meats and decent carb sources like basmati rice. no refined sugars. I had vitamins and minerals tested and I am deficient in them all I also have SIBO and Candida. I did Stool tests, Amino Acid and organic acid tests. I have really high Beta-alanine, Anserine and Carnosine levels. I Take all the B Vitamins, Folate, Zinc, Copper, Iron, Vit D, E, A, K and selenium to replace what im low in aswell as Bile Acids and Betaine HCl. Im not getting anywhere with this, I just dont know what to do. Could it be a GABA/Glutamate issue and what can I do ? i get the impression my brain is overstimulated to a rediculous degree. Ive tried memantine, L-theanine and Phenibut didnt do anything unfortunately. I tried Lamotrigine, but got a small rash before I reached 200mg so I had to quit it. I sometimes wonder if im in a state of overmethylation as people like to talk about but I dont understand it well. i take 500mg Niacinamide, will this have the same effects on calming down the methylation cycle as Niacin?