New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
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Illness trajectories in the CFS: a longitudinal study of improvers versus non-improve

Discussion in 'Latest ME/CFS Research' started by Dolphin, Jun 17, 2011.

  1. Dolphin

    Dolphin Senior Member

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    * I gave each line its own paragraph
     
  2. Dolphin

    Dolphin Senior Member

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    As I put the time into reading it, I thought I'd write a little on it.

    Definition of improvement:
    It was interesting that the improved group did tend to score higher on quite a few measures even though only this one measure was used.

    ----
    Definition of somatization/somatizers seems far from exact:
    The questions are something like the following (I was looking at a list for the SCL-90-R but I couldn't copy from that so I amalgamated two)

    In
    , the authors (i.e. a different team) used this subscale (i.e. the scores from these questions) as a measure of physical symptoms.
     
  3. WillowJ

    WillowJ คภภเє ɠรค๓թєl

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    the "somatization" scale sounds like it should have been named a "severe" group instead
     
  4. oceanblue

    oceanblue Guest

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    Another depressing study set up to confirm the authors own views.

    Thanks for digging this out. Could you say what the sample size was, how many improved and how big was the improvement?

    As far as I can tell, 4 of these 12 directly relate to the case definition for CFS:
    So severity of these might well be expected to correlate with reduced chance of improving.
     
  5. Dolphin

    Dolphin Senior Member

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    [​IMG]

    [​IMG]

    [​IMG]
     
  6. Dolphin

    Dolphin Senior Member

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    I find this discussion of outcome measures interesting. It is of course slanted to justify what they did - but whether it's practical or not, I think the bit in bold is interesting:
    The also touched on this in the introduction:
    (Bascially what they seem to be talking about is a regression line - where they may have different numbers of data points depending on how many appointments people went)
     
  7. Dolphin

    Dolphin Senior Member

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    They do admit that the model may not be that useful in clinical practice:
    I would say they may/will probably need to measure some biological factors.
     
  8. Dolphin

    Dolphin Senior Member

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    Possible error in Table 2

    I just E-mailed this:
     
  9. oceanblue

    oceanblue Guest

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    Blimey, that's unusually honest of them. And thanks for posting the info I asked for as well as you other comments. It's an interesting-looking study but my brain is a little faded at the moment.
     
  10. Esther12

    Esther12 Senior Member

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    Just from the bits Dolphin pulled out, there were a few parts where they didn't seem to try to cover up the limitations of their work. I like!

    re the Somatization scale: My score would really depend upon how much I done in that two week period. If I'd had to push myself, and make myself feel worse, I'd score much higher than if I'd had a couple of weeks of being able to set my own activity levels to an amount I was comfortable with. I'd have thought that many here would be the same.
     
  11. Dolphin

    Dolphin Senior Member

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    Yes, and these aren't always under people's own control - different people can have more external pressures of one sort or another (i.e. it's not simply an "internal" matter everyone can always control).

    My guess, based on the way some of the limitations were written it and their placing, is that a reviewer prompted them (they have the feel of stuff that is stuck in a bit). But these aren't the worst team of authors either.
     
  12. Esther12

    Esther12 Senior Member

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    That would be a shame. I'm always excited by hints of intellectual honest in CFS papers. (I can't believe how low my expectations are for CFS research!)
     
  13. oceanblue

    oceanblue Guest

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    Just been looking at the SCL-90 Somatization subscale myself and wondered if your list was from a source or your assumption having read the list of all 90 Qs?

    I wasn't sure about the 'lump in throat' question as a somatic item and wondered about these:
    Heart pounding or racing
    Trembling or shaking
    Poor appetite

    But it can't be all of them! Any thoughts welcome.
     

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