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IL17a - Undo Autism?

Discussion in 'Other Health News and Research' started by roller, Jan 28, 2016.

  1. roller

    roller wiggle jiggle

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    Read more:http://www.dailymail.co.uk/sciencetech/article-3421329/Have-scientists-cure-autism-Blocking-specific-cells-pregnancy-help-prevent-disorder-developing.html
     
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  2. minkeygirl

    minkeygirl But I Look So Good.

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    Left Coast
    I think I just read that baicalin works on th17.
     
    Last edited: Jan 28, 2016
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  3. roller

    roller wiggle jiggle

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    RESEARCH ARTICLE
    The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring

    †Corresponding author. E-mail:charles.hoeffer@colorado.edu(C.A.H.);dan.littman@med.nyu.edu(D.R.L.);jun.huh@umassmed.edu(J.R.H.) .*These authors contributed equally to this work

    Science 28 Jan 2016: pp.
    DOI: 10.1126/science.aad0314


    "Viral infection during pregnancy has been correlated with increased frequency of autism spectrum disorder (ASD) in offspring. This observation has been modeled in rodents subjected to maternal immune activation (MIA). The immune cell populations critical in the MIA model have not been identified. Using both genetic mutants and blocking antibodies in mice, we show that retinoic acid receptor–related orphan nuclear receptor γt (RORγt)–dependent effector T lymphocytes [e.g., T helper 17 (TH17) cells] and the effector cytokine interleukin-17a (IL-17a) are required in mothers for MIA-induced behavioral abnormalities in offspring. We find that MIA induces an abnormal cortical phenotype, which is also dependent on maternal IL-17a, in the fetal brain. Our data suggest that therapeutic targeting of TH17 cells in susceptible pregnant mothers may reduce the likelihood of bearing children with inflammation-induced ASD-like phenotypes."

    http://science.sciencemag.org/content/early/2016/01/28/science.aad0314.full
     
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  4. roller

    roller wiggle jiggle

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  5. adreno

    adreno PR activist

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    Note that this was used to prevent autism-like phenotypes in offspring, not as a cure for those already born.
     
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  6. natasa778

    natasa778 Senior Member

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    interesting, thank you!

    http://www.nature.com/articles/srep17407
     
  7. minkeygirl

    minkeygirl But I Look So Good.

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    Left Coast
    It's also used as an antiviral.
     

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