Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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IGF-1 to treat autoimmune diseases?

Discussion in 'General ME/CFS News' started by Strawberry, Oct 23, 2014.

  1. Strawberry

    Strawberry Senior Member

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    Seattle, WA USA
  2. Bob

    Bob

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    I don't know anything about the drug but, after reading the article, I'd like to see it tested on ME/CFS patients.
    As far as my understanding goes, T cell dysregulation seems like an area that should be explored in ME/CFS. I don't know if it's been investigated much.

    As an aside, Dr Derya Unutmaz discussed T cells, particularly in relation to leaky gut, in a recent Solve CFS video:
     
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  3. adreno

    adreno PR activist

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    DHEA increases IGF-1.
     
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  4. Revel

    Revel Senior Member

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    A hospital in South Korea ran a trial in 2012 on the effect of fermented antler velvet on CFS patients. I think that its IGF -1 content was the main ingredient 'under the microscope' as the potential wonder cure.

    No results have been forthcoming, so I'm guessing it didn't go so well . . . :meh:
     
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  5. minkeygirl

    minkeygirl But I Look So Good.

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    When I first got sick in 94 people were all excited about antler velvet. IMO it was just some way for someone to make money off the backs of the sick.

    @adreno, how much DHEA do you need to take?
     
  6. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    The problem for me is that as far as I know we have no evidence of any T cell dysregulation in human autoimmune disease - at least not the ones I used to work on. This study is on mice and I am not convinced that the experimentally induced mouse diseases being treated have much to do with spontaneous human disease.
     
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  7. Strawberry

    Strawberry Senior Member

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    I would like to hear that answer also. I decided to do a quick google search, and found an article that I THINK is relevant. My brain isn't wanting to properly absorb the info today, but it appears 100 mg daily for 6 months? Also, results are gender specific. Maybe I should try my DHEA again...

    http://onlinelibrary.wiley.com/doi/...sCustomisedMessage=&userIsAuthenticated=false
     
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  8. adreno

    adreno PR activist

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    http://www.medscape.com/viewarticle/406925_3
     
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  9. Ema

    Ema Senior Member

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    Most women take 10-25 mg of DHEA a day.
     
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  10. helios

    helios

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    I would definitely like to trial some IGF-1 injections since my IGF levels are below normal and my T cells are also at the lowest level of normal. It would fall in same realm of GH in terms of difficulty in getting support from doctors to try it. Probably also cost wise as well.
    Yes DHEA is supposed to help boost IGF levels. I tried this a number of years ago, but had skin issues and bad hair loss on it. I have tried a couple of other supplements that also supposedly improve IGF-1 levels but have not had a blood test for quite a while to verify if my blood levels improved. They were Colostrum powder and Deca (nandrolone). I did feel healthier while I was on both..Much more so on the Deca. I have taken them again a few times since and been disappointed with the improved health effect being hardly noticeable : (
     
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  11. knackers323

    knackers323 Senior Member

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    Could this be why hgh is supposedly one of the best things for PWCFS to take to feel better?
     
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  12. Strawberry

    Strawberry Senior Member

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    I decided to try the DHEA spray again as I hadn't paid attention to if it worked last time, and found out I wasn't taking enough either. I was told to "take 15 mg one dose per day", so I did one spray per day, which is 5 mg. Oops. So this time I upped it to 3 sprays (15 mg), but had to quit after just a couple of days due to an extremely sore tongue. Not sure if it is the DHEA or not? I know my sublingual B pill makes the underside of my tongue like hamburger, so it could be the B vitamins also.
     
  13. Hip

    Hip Senior Member

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    If anyone wants to try IGF-1, it is available as a supplement in the form of deer velvet antler (the velvet coating on deer antler is naturally high in IGF-1). This is taken sublingually.

    The deer velvet antler IGF-1 I bought was the Nutronics Labs IGF-1 Plus Maximum (100,000 nanograms). By taking a sublingual dose of 140 nanograms of IGF-1 (which equates to one drop of this product), I found it improved my sleep (I slept a bit deeper). More than two drops of this product, though, and I found it creates an aggressive energy and disposition, which I don't like.

    Cheaper and purer IGF-1 can be found on the websites that sell peptide hormones to body builders, such as this one and this one.
     

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