I am seeing my Rheumatologist tomorrow and last time we spoke he mentioned all the disease modifiers he had used on Ankylosing Spondylitis (which I developed at the same time as POTS/CFS). One was Ritixumab. he is however pushing for TNF alpha inhibitors like Humira. I was going to jump on the Humira but then I heard some scary stories about development of MS or the local guy that died 9 months after starting it of blood cancer. While Im far from well and I guess I dont have a huge amount of quality of life to defend particularly during relapses, I seriously dont need any other problems to deal with... So Im wondering whether I should pursue Ritixumab for AS with the chance it might also improve POTS??