Is your brain going OW, OW, OW yet? I think this forum can be overwhelming for anyone trying to figure out where they are going to start. You may have heard about Dr. Ben Lynch's site by now if you've been doing a lot of reading. I found one article on how he treats C677T mutations and it includes a stepwise protocol about how to use methylB12 and methylfolate - how much to use, when and how to take them, etc. http://mthfr.net/mthfr-c677t-mutation-basic-protocol/2012/02/24/ If you scroll down to Part II on that page, the first sentence says: Methylfolate Recommendations for those homozygous for the C677T MTHFR Mutation From there forward you can see the stepwise recommendations. Dr. Lynch has his own line of supplements, but you can certainly use your own. For a while he was accepting new patients, but as of last fall he stopped because of a full schedule. What we refer to as "startup" at Phoenix Rising, he calls "detox." I don't know which term is more accurate, but they seem to be the same constellation of symptoms. I can't say whether you should be tested for the C677T mutation. I don't have the means to afford the test or to be seen by a nutritionally-oriented doctor, so I'm just going to see how I respond to the supplements and go from there. Best of luck to everyone.