May 12, 2017 Is International ME/CFS and FM Awareness Day
International ME/CFS and FM Awareness Day is May 12th, 2017. Jody Smith shares some information about upcoming events and ways you can be heard ...
Discuss the article on the Forums.

Idiopathic chronic fatigue in older adults...

Discussion in 'Other Health News and Research' started by pattismith, Dec 3, 2017.

  1. pattismith

    pattismith Senior Member

    Messages:
    727
    Likes:
    1,006
    Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle

    Abstract
    Fatigue is a symptom of many diseases, but it can also manifest as a unique medical condition, such as idiopathic chronic fatigue (ICF). While the prevalence of ICF increases with age, mitochondrial content and function decline with age, which may contribute to ICF. The purpose of this study was to determine whether skeletal muscle mitochondrial dysregulation and oxidative stress is linked to ICF in older adults. Sedentary, old adults (n = 48, age 72.4 ┬▒ 5.3 years) were categorized into ICF and non-fatigued (NF) groups based on the FACIT-Fatigue questionnaire.
    ICF individuals had a FACIT score one standard deviation below the mean for non-anemic adults > 65 years and were excluded according to CDC diagnostic criteria for ICF.

    Vastus lateralis muscle biopsies were analyzed, showing reductions in mitochondrial content and suppression of mitochondrial regulatory proteins Sirt3, PGC-1╬▒, NRF-1, and cytochrome c in ICF compared to NF.

    Additionally, mitochondrial morphology proteins, antioxidant enzymes, and lipid peroxidation were unchanged in ICF individuals.

    Our data suggests older adults with ICF have reduced skeletal muscle mitochondrial content and biogenesis signaling that cannot be accounted for by increased oxidative damage.
     
  2. Chocolove

    Chocolove Tournament of the Phoenix - Rise Again

    Messages:
    532
    Likes:
    861
    Since mitochondrial biogenesis improves with exercise, I wonder how much they will improve with regular exercise adapted to any infirmities.

    Cellular mitochondrial biogenesis is critical to muscle aerobic capacity. It improves with exercise and declines with aging [273]. The vast majority (90%) of the energy needs in the human body rely on mitochondrial oxidative phosphorylation (OXPHOS).
    Mitochondrial biogenesis - an overview | ScienceDirect Topics
    www.sciencedirect.com/topics/biochemistry-genetics-and.../mitochondrial-biogenesis
     
    Countrygirl and Learner1 like this.
  3. Chocolove

    Chocolove Tournament of the Phoenix - Rise Again

    Messages:
    532
    Likes:
    861
    @pattismith This referenced article notes the lack of mitochondria in the elderly and proposes supplementation of PQQ for biogenesis of mitochondria:
    http://www.lifeextension.com/magazine/2010/ss/rejuvenate-your-cells-growing-new-mitochondria/page-01
     
  4. Chocolove

    Chocolove Tournament of the Phoenix - Rise Again

    Messages:
    532
    Likes:
    861
    @pattismith The elderly in the modern world also are frequently on multiple drugs that are bad for mitochondria.
    Adding mito-toxic drugs to being sendentary......I wonder how many mitochondria there are in active older adults who don't take such drugs, but eat food from a more natural environment...

    [PDF]Table of Reported Drugs with Mitochondrial Toxicity - MitoAction
    www.mitoaction.org/toxins

    Table of Reported Drugs with Mitochondrial Toxicity. Pharmacologic. Category. Toxin. Action. Symptoms. 1. Anticonvulsants. Valproate (Depakote). Sequesters carnitine; decreases fatty acid oxidation, Krebs, ETC activity and oxidative- phosphorylation; complex IV inhibition. Hepatopathy. 2. Psychotropic a. Antidepressants.
     
    Learner1 likes this.
  5. pattismith

    pattismith Senior Member

    Messages:
    727
    Likes:
    1,006
    @Chocolove , it may be interesting to dig in markers they found for chronic fatigue in these elderlies:

    Sirt3 impairment is an important aging factor.

    I've found this recent study that says Ashwagandha may be a good rescue factor.

    More on Ashagandha

    PGC 1 drives NAD synthesis. It can be activated via the Sirt1/AMPK patway. Luteolin may be interesting to rescue it.

    More on Luteolin

    you have also quoted another sirt1 rescuer here, Rutin :)

    and you also quoted Quercitine here as a PGC1 activator :)

    I don't mean that aging is similar to ME/CFS, but these supplements have multi functions and are often used by PR members, so it is good to know what they are doing on mitochondria apart from their anti-oxydant properties.
     
    Chocolove likes this.
  6. Chocolove

    Chocolove Tournament of the Phoenix - Rise Again

    Messages:
    532
    Likes:
    861
    Luteolin...What would we do without plants. Well, when one is sedentary one may not end up getting the best of nutrition (whether one is old or young) particularly with regard to plants which many people avoid because of prep issues unless they blenderize them, or because of their short shelf life, or due to mild flavor.

    There are some interesting commonalities between the sedentary elderly and folks with CFS particularly in the mitochondrial arena.

    Luteolin is a common flavonoid abundantly present in several plant products, including broccoli, pepper, thyme, and celery.
    Luteolin - an overview | ScienceDirect Topics
    https://www.sciencedirect.com/topics/pharmacology-toxicology-and...science/luteolin
     

See more popular forum discussions.

Share This Page