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Identification of replication competent gammaretroviruses in PC cell lines

Discussion in 'XMRV Research and Replication Studies' started by currer, Jan 6, 2012.

  1. currer

    currer Senior Member

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  2. Marco

    Marco Grrrrrrr!

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    Near Cognac, France
    Anyone like to hazard a guess at the implications of these two statements?

    My uninformed opinion would be that (a) BSL level 2 is inappropriate when handling these cell lines or similarly infected biologicals and/or (b) any infected cell lines/biologicals should be withdrawn from research use due to the currently unknown potential confounding impact on any experiments.

    Any thoughts?
     
  3. currer

    currer Senior Member

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    Hi Marco,

    This problem - the confounding effect of contaminating retroviruses on the outcome of research was discussed in scientific journals years ago - the late eighties if I remember correctly - the problem was that admitting that your research had been carried out on contaminated cell lines could undo years of work and the reputation that goes with it - hence researchers colluded in silence on this problem.

    For far too long by the look of it.
     

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