Obviously feeling perfect would be my initial answer to the question posed . In all seriousness though I am trying to fine tune dosing of methylfolate in particular. I can take enough to get my blood pressure to start elevating (125 -> 135) sinuses start to clear (mucus thins) pulse starts to rise (60s -> 80s) At some point though I start urinating so frequently that my blood pressure starts to drop and my pulse starts getting over 90bpm. Obviously this is due to the electrolyte loss which I compensate for. What kind of response should I be trying to maintain?