I started methylation a few weeks ago first with Methyl B-12 shots and then added in 5-MTHF (capsules.). I am compound heterozygous on MTHFR genes. I started the B-12 shots at 5 mg/ml and started the folate at 1/4 of a 2.5 capsule. All was fine for two wks so I upped the shots to 6 mg and the folate to 1/2 capsule and still fine. Well, today I upped the shot to 7 mg and the folate to the full capsule of 2.5 mg. I ate breakfast and took my other supplements. I started to feel wired, agitated, jittery and shakey. I was typing at computer and got sudden headache, felt like I could throw up (but didn't) and my HR went up to 140 bpm. Thank God my husband was home b/c my HR wouldn't go down and I started to panic. He gave me 1/2 Atenolol (which I have not needed in a week b/c no tachy) and gave me potassium, magnesium, salt tablets & Niacin which I knew from @caledonia can reverse over methylation. I have been laying down and feel much better now. Today was the first time I took the 2.5 mg of Folate and will not to that again! Does this sound like over methylation and did I handle it right? Is it okay if I go back down to the half capsule of Folate again? I'd love to hear any feedback and advice b/c I want to continue with the methylation supplements.