Edema may be a sign of heart failure. Have you ruled that out? Heart failure is one of the classic signs of vitamin B1 deficiency, but cognitive performance and mood have also been reported to be improved with B1 supplementation. And Dr Derrick Lonsdale has successfully treated swollen glands with B1. I am bringing up the possibility of B1 deficiency because among members here who have reported problems after starting the methylation protocol, several report that their problems appear to have been corrected by taking vitamin B1.