Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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I need some Help with interpreting my NutrEval.

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by NorCalGal, Dec 7, 2016.

  1. NorCalGal

    NorCalGal

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    hi. i've recently received the results from my NutrEval which my FM doctor ordered to find out more about my hypothyroid issues. She didn't go into much detail when reviewing the results, just put me on a sleuth of supplements. Which is why i'm turning to this forum as it looks to me as if my gut is all over - high malabsorption, high dysbiosis, low amino acids, low Bs, low glutathianone and high mercury, just to name a few. And i'm on "partial ketosis"? Could anyone with more knowledge about the cycle please take another look? I've looked at the very helpful Nutreval Evaluation Guide but am getting stuck on the "So what does the mean". Thank you so much.
     

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  2. NorCalGal

    NorCalGal

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    Here is a list of all the outliers... It's loooong.

    Malabsorption and Dysbiosis Markers

    Malabsorption Markers

    Indoleacetic Acid (IAA) - High

    Phenylacetic Acid (PAA) - Very High

    Bacterial Dysbiosis

    DHPPA - Somewhat High

    3-Hydroxyphenylacetic Acid - Very High

    4-Hydroxyphenylacetic Acid - Somewhat High

    Benzoic Acid - Very High

    Hippuric Acid < dl

    Yeast/Fungal Dysbiosis

    Citramic Acid - Very High

    Tartaric Acid < dl

    Cellular Energy and mitochondrial Metabolites

    Carbohydrates Metabolism

    BHBA - Very High

    Energy Metabolism

    Cis-Aconitic Acid - Somewhat Low

    AKG - Somewhat High

    Succinc Acid < dl

    Malic Acid - Very High

    Beta-OH-Beta-Methylglutaric Acid < dl

    Fatty Acid Metabolism

    Suberic Acid < dl

    Creatinine Concentration

    Creatinine - Very Low

    Neurotransmitter Metabolites

    Homovanilic Acid - Very High

    5-OH-indoleacetic Acid - Very High

    3-Methyl-4-OH-phenylglycol - Very High

    Quinolinic Acid < dl

    Vitamin Markets

    a-Ketoadipic Acid - Very High

    a-Ketoisovaleric Acid - High

    a-Ketoisocaproic Acid - High

    a-Keto-B-Mehylvaleric Acid - High

    FiGlu < dl

    Glutaric Acid - Very High

    Isovaleryglycine - Very High

    Methylmaloric Acid - Very High

    Xanthurenic Acid - < dl

    3-Hydroxypropionic Acid - Barely normal

    b

    a-ketophyenylacetic Acid - Very High

    a-Hydroxyisobuyric Acid - Very High

    Orotic Acid - Somewhat High

    Pyroglutamic Acid - Somewhat High

    Tyrosine Metabolism

    Homogentisic Acid - Very High

    2-Hydroxyphenylacetic Acid - Very High


    Nutritionally Essential Amino Acids

    Arginine - Very Low

    Isoleucine - Very Low

    Methionine - Very Low

    Valine - Very Low

    Nonessential Protein Amino Acids

    Cyst(e)ine Very High

    y-Aminobutyric Acid < dl


    Intermediary Metabolites

    a-Aminoadipic Acid - Very High

    a-Amino-N-Butyric Acid - Somewhat Low

    b-Aminoisobutyric Acid < dl

    Cystathionine < dl

    Urea Cycle

    Citruline - Borderline Low

    Glycine/Serine Metabolites

    Ethanolamine - Somewhat Low

    Phosphoserine - Very Low

    Sarcosine < dl

    Dietary Peptide Related Markets

    b-Alanine < dl


    Toxic Elements
    Mercury - Very High

    Antimony - Borderline
     
  3. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    If you go the Caledonia’s Methylation Links, you will find a Nutreval Interpretation Guide that is a summary of the posts on the subject by a very intelligent former member.
     
  4. NorCalGal

    NorCalGal

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    Thank you.
    Here is a summary of what I understand based on the Caledonia's Methylation Links. Thank you Caledonia for helping us all!

    1. Deficiency in B Vitamins: is it because co-factor inefficiencies or toxins?
    2. Metabolizing Fats leading to higher Adipic and <dl Suberic acid.
    3. Beta-OH-Butyric Acid is a metabolic marker of blood sugar utilization and insulin function. Consider supplementing with chromium, vanadium, and lipoic acid. Why is my body not burning carbs to provide energy to the cells and instead burns fat? Something wrong with carbs metabolism? Maybe related with hypothryoidism.
    4. Ok that Beta-OH-Beta_Methyglutaric Acid is <dl?
    5. Succinate <dl may be impaired due to low cofactors (Fe or B2) or bacterial degradation of glutamine.
    6. Dysbiosis markers high reflecting intestinal overgrowth usually accompanied by microbial hyper permeability (aka leaky gut). Glutamine 10-20 mg, digestive aids (betaine, enzymes, bile) and free-form amino acids to help normalize gut permeability.
    7. High Methylmalonic Acid due to B12 deficiency - or malabsorption of B12?
    8. Dysbiosis:
      1. diet changes, pre- and probiotics, mucosal support, and possibly further testing such as a stool test or immune reactions from food
      2. specifically against high DHPPA: Saccharomyces boulardii
      3. average arabinose: no yeast/candida?
    9. High alpha-hydroxyisobutyric Acid: limited glutathione production?
    10. Pyroglutamic and α-hydroxybutyrate slightly elevated - high toxin markers: need for glycine - relevant that Isovaleryglycine is elevated? Didn’t find Sulfate indication?
    11. Quinolinic Acid so low thanks to LifeVantage (a supplement I’m taking)- sustainable?
    12. Neurotransmitter Metabolism/Serotonin Marker: Homovanillic high, 5Hydroxyindoleacetic acid high: Vitamin C or NAC? Why? Inflammation leads to changing serotonin pathways. Hypothyroidism response to stress. Need to solve for inflammation. Toxicity through mercury could also be the issue. Hormones (cortisol), poor digestion/malabsorption, SIBO…
    13. Tyrosine Metabolism: 2-Hydroxyphenylacetic Acid high. Due to lack of Vitamin C - 100-150 mg p/d? Also high homovanillic so implied overproduction/inefficiency of dopamine production?
    14. Glutamic Acid: low so need to supplement with B2
    15. HMG <dl and BHBA high: Ketosis from carbohydrate unavailability (e.g., fasting, diabetes, strenuous exercise, ketogenic diet).
    16. Mercury super high and even higher on Doctor’s Data post provoked test - in fact, off the charts!
     

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