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I need DAO SNP help.

Discussion in 'Mast Cell Disorders/Mastocytosis' started by UM MAN, Apr 14, 2013.

  1. UM MAN

    UM MAN

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    My 23andMe raw data lists 11 DAO SNPs. 7 are heterz, 4 homoz.
    The 4 homoz SNPs are wild type or compliment, so I assume that they normal.

    My question, to you all, is, how many of your 11 DAO SNPs are heterz?????

    I suspect that I have an DAO enzyme deficency.
     
  2. globalpilot

    globalpilot Senior Member

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    I'm homozygous for all. Now some of those might be homozygous polymorphisms. I don't know.
    Have you considered the diamine oxidase activity test ?

    I see you are taking histame ? How is that working out ? Has it relieved any symptoms ?
     
  3. Sea

    Sea Senior Member

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    I have 7 hetero, 4 homo wild type
     
  4. UM MAN

    UM MAN

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    DAOSIN/HISTAME work really well for me. I have no GI issues from histamine, it is my, neck up mastcells.
    I use one DAOSIN per meal, and this gets expensive. I wish I could freeze dry my own pig kidneys.

    At one point I considered small SubQ Heparin injections.

    If the DAO test ever is offered by LABCORP, I'll do it.
    I'm pretty confident, that T4 (synthroid) destroyed my DAO level, the problem is finding a way
    to stimulate DAO production. When my DAO level was suppressed, I had to rely on HNMT, and methyl, to clear histamines, and my SNPs make me undermethylated, so HNMT could not find enough methly doners to make up for the lack of DAO.
     
  5. UM MAN

    UM MAN

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    Do you suspect that you have a DAO deficiency??
     
  6. globalpilot

    globalpilot Senior Member

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    I do think it's a definite possibility. I have been reading a lot about histamine and DAO etc lately. There are some DAO SNPs reported in the literature to decrease DAO activity that 23andme does not report.

    Do you mean you never had GI issues from histamine or do you mean the histame removed the GI issues ?

    My doctor is suggesting mast cell activation is responsible for my spaciness and bloating.
     
  7. UM MAN

    UM MAN

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    My GI track has never been any issue in my entire life, even after T4 destroyed my DAO levels.
    DAOSIN/HISTAME obviously must also get from my GI track, into my blood system, because
    it affects the histamine reactions in my ears and mouth.
     
  8. Sea

    Sea Senior Member

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    I've no idea. It's not an area I am at all familiar with
     
  9. jepps

    jepps Senior Member

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    Do you know, what are the SNP´s for DAO?

    And I cannot open the raw data´s on the Homepage of 23andMe. How can I find them?

    Thank you for your reply!
     
  10. Valentijn

    Valentijn Activity Level: 3

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  11. jepps

    jepps Senior Member

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    Thank you very much Valentijn!
    And if my version is the same as my Genotype, then I don´t have a mutation. If my version is another, then I have a mutation, right or not??????
    Do you have a link for me how to interpret the raw datas?

    Greetings jepps
     
  12. Valentijn

    Valentijn Activity Level: 3

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    A "mutation" is simply a variation of genotype. Variation is completely normal, and often means absolutely nothing.

    To know if a mutation (your genotype) has any impact, you need to read the research or find a trustworthy source who has read it.
     
  13. jepps

    jepps Senior Member

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    Thank you, I understand, and kind regards.
     
  14. ahmo

    ahmo Senior Member

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    @Valentijn, I followed your link for 23andme DAO. I use SNPtips for Firefox, and the whole list of SNPs are highlighted, see below. Does this mean that all my DAO SNPs are impacting me? Or is this what you're referring to, and I need to research each one, when you say,
    Thanks, ahmo



    upload_2013-12-30_13-21-0.png
     
  15. Valentijn

    Valentijn Activity Level: 3

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    It means you need to research them to see if they have an impact. One good source is scholar.google.com . Another is http://www.ncbi.nlm.nih.gov/projects/SNP/ (hover over a pale blue box that appears attached to the green line in the map view to get a list of links to research).

    Looking at my spread sheet with full 23andMe data from 11 ME/CFS patients and 14 controls, you have the completely normal and more common versions of each SNP. Hence it's very unlikely that they would have a significantly negative impact.
     
  16. acer2000

    acer2000 Senior Member

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    I have the exact same DAO snps as ahmo. I tried taking HISTAME and it didn't seem to help much. HNMT is in there too. But again, not sure I know how to read it to see which ones are good or bad.
     
  17. ahmo

    ahmo Senior Member

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    @Valentijn, Thanks. I do, in fact, have histamine issues, think I'm somewhere on the mast cell spectrum, as well as my homozygous MAO SNP, so I'll be interested to follow this up. On first look at the link, I can't make much more sense of it than I can from 23andme or Promethease. I guess as a genetic illiterate, this might be as good as it gets. cheers, ahmo
     
    Last edited: Dec 30, 2013
  18. finalgates

    finalgates

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    why you think t4 destroyed your DAO?you take t3 now?
     

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