- Messages
- 27
Hello!
This is my first post on the forum. While I do not have ME/CFS, there are a lot of discussions on this forum about methylation/OCD and similar issues, so I allowed myself to post too.
My problem is mainly OCD, anxiety, high stress for almost any reason,
I have no physical symptoms of any kind, in fact physically I have higher then average energy during the day. It's just mentally I am getting so stressed every day, while I do not have a stressful life at all, but almost anything can stress me, like a noise, people. Social anxiety of course. OCD expresses itself in inability to let go of anything I am doing, so I start doing a minor thing, and it uses up most of my day. Sometimes high anxiety kicks in so I am unable to focus and get anything done as I am constantly worrying about something, millions thoughts going through my head.
Got my 23andme results recently, here is the Genetic Genie report:
Gene & Variation rsID Alleles Result
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 TT +/+
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 GG -/-
ACAT1-02 rs3741049 AG +/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 __ no call
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 __ no call
MTRR A664A rs1802059 AA +/+
BHMT-02 rs567754 TT +/+
BHMT-04 rs617219 __ no call
BHMT-08 rs651852 TT +/+
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 __ no call
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 AA +/+
CBS N212N rs2298758 __ no call
SHMT1 C1420T rs1979277 __ no call
Here are the supplements I am currently taking:
=======================================================================
[EMPTY_STOMACH] Just after wake-up
-----------------------------------------------------------------------
[MINERAL] 4g CALM magnesium citrate powder (350mg Mg)
[MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
[AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
[AMINO-ACID] 0.5g Taurine powder
[AMINO-ACID] 6g Creatine Monohydrate powder
[AMINO-ACID] 10g L-Glutamine powder
[AMINO-ACID] 1x 500mg NAC capsule
[MINERAL] 1x Thorne PIC-MINS capsule (15mg Zn, 2.5mg Mn, 100mcg Se, 100mcg Cr, 50mcg Mo, 0.7mg B, 50mcg V)
[VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[WITH_FOOD] During/after breakfast (usually bulletproof coffee, avocados, eggs)
-----------------------------------------------------------------------
[MINERAL] 1x Super Natural Boron capsule (3mg B from 112mg Calcium Fructoborate)
[MINERAL] 1x LifeExtension Se-Methyl-L-Selenocysteine capsule (200 mcg Se)
[MINERAL] 0.5x Iodoral IOD-50 tablet (25 mg I)
[VIT] 1x Swanson B-complex capsule (with 25mg P5P)
[OTHER] 1x Thorne Calcium-D-Glucarate capsule (500mg)
[OTHER] 1x viridian Organic Ashwagandha Extract 5% capsule (300mg)
[FAT-VIT] 1x Olympian Labs vitamin E complete 200 IU softgel
[FAT-VIT] 2 drops Thorne vitamin D/K2 liquid (1000 IU D3, 200 mcg K2-MK4)
[VIT] 0.25g Inositol powder
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[EMPTY_STOMACH] At least 30-60 minutes before dinner
-----------------------------------------------------------------------
[MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
[AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
[AMINO-ACID] 0.5g Taurine powder
[AMINO-ACID] 10g L-Glutamine powder
[AMINO-ACID] 1x 500mg NAC capsule
[MINERAL] 1x Thorne Magnesium Citramate capsule (135mg Mg)
[MINERAL] 1x Thorne double strenght Zinc Picolinate capsule (30mg Zn)
[VIT] 1x metabolics P-5-P capsule (with 34mg P5P)
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[WITH FOOD] During/after dinner (big, cooked meal: meat/fish, vegetables, butter)
-----------------------------------------------------------------------
[MINERAL] 4ml TraceMinerals Mega-Mag liquid (400mg Mg, 1.5mg B)
[MINERAL] 1x LifeExtension Only Trace Minerals capsule (20mg Zn, 2mg Cu, 2mg Mn, 400mcg Cr, 250mcg Mo, 3mg B, 750mcg V)
[MINERAL] 1x Super Natural Boron capsule (3mg B from 112mg Calcium Fructoborate)
[MINERAL] Mon, Wed, Fri: 1x Thorne Molybdenum Glycinate capsule 1mg (429mcg Mo/day)
[MINERAL] 1x Vitacost L-selenomethionine Selenium SeLECT capsule (200 mcg Se)
[MINERAL] 0.5x Iodoral IOD-50 tablet (25 mg I)
[FAT-VIT] 1x Olympian Labs vitamin E complete 200 IU softgel
[FAT-VIT] 1x Healthy Origins Vitamin D3 10000 IU softgel
[FAT-VIT] 1x Nature's Plus Vitamin K2-MK7 120mcg capsule
[VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
[OTHER] 1x Thorne Calcium-D-Glucarate capsule (500mg)
[OTHER] 1x viridian Organic Ashwagandha Extract 5% capsule (300mg)
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[EMPTY STOMACH] Before bed, at least 1-2 hours after dinner
-----------------------------------------------------------------------
[MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
[AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
[AMINO-ACID] 0.5g Taurine powder
[AMINO-ACID] 10g L-Glutamine powder
[MINERAL] 2.2g Magnesium Glycinate powder (400 mg Mg)
[MINERAL] 1x Lithium Orotate capsule (5 mg Li)
[VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
[AMINO-ACID] 1x 500mg NAC capsule
[OTHER] 16g raw honey
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
DAILY TOTALS
-----------------------------------------------------------------------
[MINERAL] Mg: 350+135+400+400+3*60 = 1465mg
[MINERAL] Zn: 15+30+20 = 65mg
[MINERAL] Cu: 2 = 2mg
[MINERAL] Mn: 2.5+2 = 4.5mg
[MINERAL] B: 0.7+3+1.5+3+3 = 11.2mg
[MINERAL] Mo: 50+250+429 = 729mcg
[MINERAL] V: 50+750 = 800mcg
[MINERAL] Cr: 100+400 = 500mcg
[MINERAL] Se: 100+200+200 = 500mcg
[MINERAL] I: 25+25 = 50mg
[MINERAL] Li: 5 = 5mg
[MINERAL] Ge: 3*10.8 = 32.1mg
[FAT-VIT] Vitamin D3: 11000 IU
[FAT-VIT] Vitamin K2-MK4: 200 mcg
[FAT-VIT] Vitamin K2-MK7: 120 mcg
[FAT-VIT] Vitamin E: 400 IU
[VIT] Vitamin B1: 15mg as Thiamine Pyrophosphate
[VIT] Vitamin B1: 25mg as Benfotiamine
[VIT] Vitamin B2: 40.3mg as Riboflavin-5'-Phosphate
[VIT] Vitamin B3: 37.5mg as Niacinamide
[VIT] Vitamin B3: 50mg as Niacin from 62.5mg Inositol Hexanicotinate
[VIT] Inositol: 12.5mg from Inositol Hexanicotinate
[VIT] Inositol: 37.5mg from Inositol
[VIT] Choline: 150mg as Choline Bitartrate
[VIT] Choline: 25mg as Choline Citrate
[VIT] Vitamin B5: 37.8mg as Calcium D-Pantothenate
[VIT] Vitamin B5: 25mg as Pantethine
[VIT] Vitamin B6: 74.6mg as Pyridoxal-5'-Phosphate
[VIT] Biotin: 175mcg
[VIT] Vitamin B9: 400mcg as Quatrefolic - Folate (as (6S)-5-Methylfolate, glucosamine salt)
[VIT] Vitamin B9: 600mcg as Metafolin - Folate (as Calcium Folinate / calcium L-5-methyltretrahydrofolate)
[VIT] PABA: 25mg Para Amino Benzoic Acid (folic acid precursor)
[VIT] Vitamin B12: 375mcg as Adenosylcobalamin
[VIT] Vitamin B12: 3125mcg as Methylcobalamin
[AMINO-ACID] Trimethylglycine (TMG): 1950mg
[AMINO-ACID] Creatine Monohydrate: 6g
[AMINO-ACID] L-Glutamine: 30g
[AMINO-ACID] Taurine: 1500mg
[AMINO-ACID] N-Acetyl-Cysteine (NAC): 1500mg
[OTHER] Calcium-D-Glucarate: 1000mg
[OTHER] Organic Ashwagandha Extract 5%: 600mg
[OTHER] raw honey: 16g
=======================================================================
I also have green, mushy stools (not full diarrhea most days, but they are not formed, and become a mushy ball in the toilet), so I am trying to see what triggers it (sometime I was able to have proper brown formed stools for some days) that's why I am not taking any vitamin C or high-dose Inositol, just because they can cause diarrhea. Magnesium is NOT the problem, I already tested that I did have perfectly formed stools for some days even with this much magnesium. But even a teaspoon of salt in water or 360mg potassium as citrate makes my stool way more mushy (potassium gave me severe diarrhea).
I am looking for advice what to do about my SNPs, what to adjust in my supplementation, as so far I had not much success in treating my anxiety, OCD and stress, although many of the supplements I introduced only recently.
I urine-tested for very mild, doubtful pyroluria. Based on symptoms described in Dr. Walsh book "Nutrient Power" I suspect I am undermethylated, likely low-serotonin.
If anyone has any suggestions what might adjust in my supplementation, in relevance to my genetic mutations. Also if some of the supplements should be moved to a different time - like take them on empty stomach instead of with food (or vice versa).
This is my first post on the forum. While I do not have ME/CFS, there are a lot of discussions on this forum about methylation/OCD and similar issues, so I allowed myself to post too.
My problem is mainly OCD, anxiety, high stress for almost any reason,
I have no physical symptoms of any kind, in fact physically I have higher then average energy during the day. It's just mentally I am getting so stressed every day, while I do not have a stressful life at all, but almost anything can stress me, like a noise, people. Social anxiety of course. OCD expresses itself in inability to let go of anything I am doing, so I start doing a minor thing, and it uses up most of my day. Sometimes high anxiety kicks in so I am unable to focus and get anything done as I am constantly worrying about something, millions thoughts going through my head.
Got my 23andme results recently, here is the Genetic Genie report:
Gene & Variation rsID Alleles Result
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 TT +/+
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 GG -/-
ACAT1-02 rs3741049 AG +/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 __ no call
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 __ no call
MTRR A664A rs1802059 AA +/+
BHMT-02 rs567754 TT +/+
BHMT-04 rs617219 __ no call
BHMT-08 rs651852 TT +/+
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 __ no call
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 AA +/+
CBS N212N rs2298758 __ no call
SHMT1 C1420T rs1979277 __ no call
Here are the supplements I am currently taking:
=======================================================================
[EMPTY_STOMACH] Just after wake-up
-----------------------------------------------------------------------
[MINERAL] 4g CALM magnesium citrate powder (350mg Mg)
[MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
[AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
[AMINO-ACID] 0.5g Taurine powder
[AMINO-ACID] 6g Creatine Monohydrate powder
[AMINO-ACID] 10g L-Glutamine powder
[AMINO-ACID] 1x 500mg NAC capsule
[MINERAL] 1x Thorne PIC-MINS capsule (15mg Zn, 2.5mg Mn, 100mcg Se, 100mcg Cr, 50mcg Mo, 0.7mg B, 50mcg V)
[VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[WITH_FOOD] During/after breakfast (usually bulletproof coffee, avocados, eggs)
-----------------------------------------------------------------------
[MINERAL] 1x Super Natural Boron capsule (3mg B from 112mg Calcium Fructoborate)
[MINERAL] 1x LifeExtension Se-Methyl-L-Selenocysteine capsule (200 mcg Se)
[MINERAL] 0.5x Iodoral IOD-50 tablet (25 mg I)
[VIT] 1x Swanson B-complex capsule (with 25mg P5P)
[OTHER] 1x Thorne Calcium-D-Glucarate capsule (500mg)
[OTHER] 1x viridian Organic Ashwagandha Extract 5% capsule (300mg)
[FAT-VIT] 1x Olympian Labs vitamin E complete 200 IU softgel
[FAT-VIT] 2 drops Thorne vitamin D/K2 liquid (1000 IU D3, 200 mcg K2-MK4)
[VIT] 0.25g Inositol powder
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[EMPTY_STOMACH] At least 30-60 minutes before dinner
-----------------------------------------------------------------------
[MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
[AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
[AMINO-ACID] 0.5g Taurine powder
[AMINO-ACID] 10g L-Glutamine powder
[AMINO-ACID] 1x 500mg NAC capsule
[MINERAL] 1x Thorne Magnesium Citramate capsule (135mg Mg)
[MINERAL] 1x Thorne double strenght Zinc Picolinate capsule (30mg Zn)
[VIT] 1x metabolics P-5-P capsule (with 34mg P5P)
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[WITH FOOD] During/after dinner (big, cooked meal: meat/fish, vegetables, butter)
-----------------------------------------------------------------------
[MINERAL] 4ml TraceMinerals Mega-Mag liquid (400mg Mg, 1.5mg B)
[MINERAL] 1x LifeExtension Only Trace Minerals capsule (20mg Zn, 2mg Cu, 2mg Mn, 400mcg Cr, 250mcg Mo, 3mg B, 750mcg V)
[MINERAL] 1x Super Natural Boron capsule (3mg B from 112mg Calcium Fructoborate)
[MINERAL] Mon, Wed, Fri: 1x Thorne Molybdenum Glycinate capsule 1mg (429mcg Mo/day)
[MINERAL] 1x Vitacost L-selenomethionine Selenium SeLECT capsule (200 mcg Se)
[MINERAL] 0.5x Iodoral IOD-50 tablet (25 mg I)
[FAT-VIT] 1x Olympian Labs vitamin E complete 200 IU softgel
[FAT-VIT] 1x Healthy Origins Vitamin D3 10000 IU softgel
[FAT-VIT] 1x Nature's Plus Vitamin K2-MK7 120mcg capsule
[VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
[OTHER] 1x Thorne Calcium-D-Glucarate capsule (500mg)
[OTHER] 1x viridian Organic Ashwagandha Extract 5% capsule (300mg)
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
[EMPTY STOMACH] Before bed, at least 1-2 hours after dinner
-----------------------------------------------------------------------
[MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
[AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
[AMINO-ACID] 0.5g Taurine powder
[AMINO-ACID] 10g L-Glutamine powder
[MINERAL] 2.2g Magnesium Glycinate powder (400 mg Mg)
[MINERAL] 1x Lithium Orotate capsule (5 mg Li)
[VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
[AMINO-ACID] 1x 500mg NAC capsule
[OTHER] 16g raw honey
[VIT] 1x sublingual methylcobalamin 500mcg
=======================================================================
DAILY TOTALS
-----------------------------------------------------------------------
[MINERAL] Mg: 350+135+400+400+3*60 = 1465mg
[MINERAL] Zn: 15+30+20 = 65mg
[MINERAL] Cu: 2 = 2mg
[MINERAL] Mn: 2.5+2 = 4.5mg
[MINERAL] B: 0.7+3+1.5+3+3 = 11.2mg
[MINERAL] Mo: 50+250+429 = 729mcg
[MINERAL] V: 50+750 = 800mcg
[MINERAL] Cr: 100+400 = 500mcg
[MINERAL] Se: 100+200+200 = 500mcg
[MINERAL] I: 25+25 = 50mg
[MINERAL] Li: 5 = 5mg
[MINERAL] Ge: 3*10.8 = 32.1mg
[FAT-VIT] Vitamin D3: 11000 IU
[FAT-VIT] Vitamin K2-MK4: 200 mcg
[FAT-VIT] Vitamin K2-MK7: 120 mcg
[FAT-VIT] Vitamin E: 400 IU
[VIT] Vitamin B1: 15mg as Thiamine Pyrophosphate
[VIT] Vitamin B1: 25mg as Benfotiamine
[VIT] Vitamin B2: 40.3mg as Riboflavin-5'-Phosphate
[VIT] Vitamin B3: 37.5mg as Niacinamide
[VIT] Vitamin B3: 50mg as Niacin from 62.5mg Inositol Hexanicotinate
[VIT] Inositol: 12.5mg from Inositol Hexanicotinate
[VIT] Inositol: 37.5mg from Inositol
[VIT] Choline: 150mg as Choline Bitartrate
[VIT] Choline: 25mg as Choline Citrate
[VIT] Vitamin B5: 37.8mg as Calcium D-Pantothenate
[VIT] Vitamin B5: 25mg as Pantethine
[VIT] Vitamin B6: 74.6mg as Pyridoxal-5'-Phosphate
[VIT] Biotin: 175mcg
[VIT] Vitamin B9: 400mcg as Quatrefolic - Folate (as (6S)-5-Methylfolate, glucosamine salt)
[VIT] Vitamin B9: 600mcg as Metafolin - Folate (as Calcium Folinate / calcium L-5-methyltretrahydrofolate)
[VIT] PABA: 25mg Para Amino Benzoic Acid (folic acid precursor)
[VIT] Vitamin B12: 375mcg as Adenosylcobalamin
[VIT] Vitamin B12: 3125mcg as Methylcobalamin
[AMINO-ACID] Trimethylglycine (TMG): 1950mg
[AMINO-ACID] Creatine Monohydrate: 6g
[AMINO-ACID] L-Glutamine: 30g
[AMINO-ACID] Taurine: 1500mg
[AMINO-ACID] N-Acetyl-Cysteine (NAC): 1500mg
[OTHER] Calcium-D-Glucarate: 1000mg
[OTHER] Organic Ashwagandha Extract 5%: 600mg
[OTHER] raw honey: 16g
=======================================================================
I also have green, mushy stools (not full diarrhea most days, but they are not formed, and become a mushy ball in the toilet), so I am trying to see what triggers it (sometime I was able to have proper brown formed stools for some days) that's why I am not taking any vitamin C or high-dose Inositol, just because they can cause diarrhea. Magnesium is NOT the problem, I already tested that I did have perfectly formed stools for some days even with this much magnesium. But even a teaspoon of salt in water or 360mg potassium as citrate makes my stool way more mushy (potassium gave me severe diarrhea).
I am looking for advice what to do about my SNPs, what to adjust in my supplementation, as so far I had not much success in treating my anxiety, OCD and stress, although many of the supplements I introduced only recently.
I urine-tested for very mild, doubtful pyroluria. Based on symptoms described in Dr. Walsh book "Nutrient Power" I suspect I am undermethylated, likely low-serotonin.
If anyone has any suggestions what might adjust in my supplementation, in relevance to my genetic mutations. Also if some of the supplements should be moved to a different time - like take them on empty stomach instead of with food (or vice versa).