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I have OCD, anxiety, likely undermethylation,very mild pyroluria

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Omega Terus, Oct 6, 2015.

  1. Omega Terus

    Omega Terus

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    Hello!

    This is my first post on the forum. While I do not have ME/CFS, there are a lot of discussions on this forum about methylation/OCD and similar issues, so I allowed myself to post too.

    My problem is mainly OCD, anxiety, high stress for almost any reason,

    I have no physical symptoms of any kind, in fact physically I have higher then average energy during the day. It's just mentally I am getting so stressed every day, while I do not have a stressful life at all, but almost anything can stress me, like a noise, people. Social anxiety of course. OCD expresses itself in inability to let go of anything I am doing, so I start doing a minor thing, and it uses up most of my day. Sometimes high anxiety kicks in so I am unable to focus and get anything done as I am constantly worrying about something, millions thoughts going through my head.

    Got my 23andme results recently, here is the Genetic Genie report:

    Gene & Variation rsID Alleles Result
    COMT V158M rs4680 AG +/-
    COMT H62H rs4633 CT +/-
    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 TT +/+
    VDR Taq rs731236 AG +/-
    MAO-A R297R rs6323 GG -/-
    ACAT1-02 rs3741049 AG +/-
    MTHFR C677T rs1801133 AG +/-
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 GT +/-
    MTR A2756G rs1805087 AA -/-
    MTRR A66G rs1801394 GG +/+
    MTRR H595Y rs10380 __ no call
    MTRR K350A rs162036 AA -/-
    MTRR R415T rs2287780 __ no call
    MTRR A664A rs1802059 AA +/+
    BHMT-02 rs567754 TT +/+
    BHMT-04 rs617219 __ no call
    BHMT-08 rs651852 TT +/+
    AHCY-01 rs819147 TT -/-
    AHCY-02 rs819134 __ no call
    AHCY-19 rs819171 TT -/-
    CBS C699T rs234706 AG +/-
    CBS A360A rs1801181 AA +/+
    CBS N212N rs2298758 __ no call
    SHMT1 C1420T rs1979277 __ no call

    Here are the supplements I am currently taking:

    =======================================================================
    [EMPTY_STOMACH] Just after wake-up
    -----------------------------------------------------------------------
    [MINERAL] 4g CALM magnesium citrate powder (350mg Mg)
    [MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
    [AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
    [AMINO-ACID] 0.5g Taurine powder
    [AMINO-ACID] 6g Creatine Monohydrate powder
    [AMINO-ACID] 10g L-Glutamine powder
    [AMINO-ACID] 1x 500mg NAC capsule
    [MINERAL] 1x Thorne PIC-MINS capsule (15mg Zn, 2.5mg Mn, 100mcg Se, 100mcg Cr, 50mcg Mo, 0.7mg B, 50mcg V)
    [VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
    [VIT] 1x sublingual methylcobalamin 500mcg
    =======================================================================
    [WITH_FOOD] During/after breakfast (usually bulletproof coffee, avocados, eggs)
    -----------------------------------------------------------------------
    [MINERAL] 1x Super Natural Boron capsule (3mg B from 112mg Calcium Fructoborate)
    [MINERAL] 1x LifeExtension Se-Methyl-L-Selenocysteine capsule (200 mcg Se)
    [MINERAL] 0.5x Iodoral IOD-50 tablet (25 mg I)
    [VIT] 1x Swanson B-complex capsule (with 25mg P5P)
    [OTHER] 1x Thorne Calcium-D-Glucarate capsule (500mg)
    [OTHER] 1x viridian Organic Ashwagandha Extract 5% capsule (300mg)
    [FAT-VIT] 1x Olympian Labs vitamin E complete 200 IU softgel
    [FAT-VIT] 2 drops Thorne vitamin D/K2 liquid (1000 IU D3, 200 mcg K2-MK4)
    [VIT] 0.25g Inositol powder
    [VIT] 1x sublingual methylcobalamin 500mcg

    =======================================================================
    [EMPTY_STOMACH] At least 30-60 minutes before dinner
    -----------------------------------------------------------------------
    [MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
    [AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
    [AMINO-ACID] 0.5g Taurine powder
    [AMINO-ACID] 10g L-Glutamine powder
    [AMINO-ACID] 1x 500mg NAC capsule
    [MINERAL] 1x Thorne Magnesium Citramate capsule (135mg Mg)
    [MINERAL] 1x Thorne double strenght Zinc Picolinate capsule (30mg Zn)
    [VIT] 1x metabolics P-5-P capsule (with 34mg P5P)
    [VIT] 1x sublingual methylcobalamin 500mcg
    =======================================================================
    [WITH FOOD] During/after dinner (big, cooked meal: meat/fish, vegetables, butter)
    -----------------------------------------------------------------------
    [MINERAL] 4ml TraceMinerals Mega-Mag liquid (400mg Mg, 1.5mg B)
    [MINERAL] 1x LifeExtension Only Trace Minerals capsule (20mg Zn, 2mg Cu, 2mg Mn, 400mcg Cr, 250mcg Mo, 3mg B, 750mcg V)
    [MINERAL] 1x Super Natural Boron capsule (3mg B from 112mg Calcium Fructoborate)
    [MINERAL] Mon, Wed, Fri: 1x Thorne Molybdenum Glycinate capsule 1mg (429mcg Mo/day)
    [MINERAL] 1x Vitacost L-selenomethionine Selenium SeLECT capsule (200 mcg Se)
    [MINERAL] 0.5x Iodoral IOD-50 tablet (25 mg I)
    [FAT-VIT] 1x Olympian Labs vitamin E complete 200 IU softgel
    [FAT-VIT] 1x Healthy Origins Vitamin D3 10000 IU softgel
    [FAT-VIT] 1x Nature's Plus Vitamin K2-MK7 120mcg capsule
    [VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
    [OTHER] 1x Thorne Calcium-D-Glucarate capsule (500mg)
    [OTHER] 1x viridian Organic Ashwagandha Extract 5% capsule (300mg)
    [VIT] 1x sublingual methylcobalamin 500mcg
    =======================================================================
    [EMPTY STOMACH] Before bed, at least 1-2 hours after dinner
    -----------------------------------------------------------------------
    [MINERAL] 5ml Bis-carboxyethyl germanium sesquioxide 1% solution (50mg Ge-132, 10.7mg Ge)
    [AMINO-ACID] 0.65g TMG powder (650mg Trimethylglycine)
    [AMINO-ACID] 0.5g Taurine powder
    [AMINO-ACID] 10g L-Glutamine powder
    [MINERAL] 2.2g Magnesium Glycinate powder (400 mg Mg)
    [MINERAL] 1x Lithium Orotate capsule (5 mg Li)
    [VIT] 1x metabolics B-complex capsule (with 5.2mg P5P)
    [AMINO-ACID] 1x 500mg NAC capsule
    [OTHER] 16g raw honey
    [VIT] 1x sublingual methylcobalamin 500mcg
    =======================================================================
    DAILY TOTALS
    -----------------------------------------------------------------------
    [MINERAL] Mg: 350+135+400+400+3*60 = 1465mg
    [MINERAL] Zn: 15+30+20 = 65mg
    [MINERAL] Cu: 2 = 2mg
    [MINERAL] Mn: 2.5+2 = 4.5mg
    [MINERAL] B: 0.7+3+1.5+3+3 = 11.2mg
    [MINERAL] Mo: 50+250+429 = 729mcg
    [MINERAL] V: 50+750 = 800mcg
    [MINERAL] Cr: 100+400 = 500mcg
    [MINERAL] Se: 100+200+200 = 500mcg
    [MINERAL] I: 25+25 = 50mg
    [MINERAL] Li: 5 = 5mg
    [MINERAL] Ge: 3*10.8 = 32.1mg

    [FAT-VIT] Vitamin D3: 11000 IU
    [FAT-VIT] Vitamin K2-MK4: 200 mcg
    [FAT-VIT] Vitamin K2-MK7: 120 mcg
    [FAT-VIT] Vitamin E: 400 IU

    [VIT] Vitamin B1: 15mg as Thiamine Pyrophosphate
    [VIT] Vitamin B1: 25mg as Benfotiamine
    [VIT] Vitamin B2: 40.3mg as Riboflavin-5'-Phosphate
    [VIT] Vitamin B3: 37.5mg as Niacinamide
    [VIT] Vitamin B3: 50mg as Niacin from 62.5mg Inositol Hexanicotinate
    [VIT] Inositol: 12.5mg from Inositol Hexanicotinate
    [VIT] Inositol: 37.5mg from Inositol
    [VIT] Choline: 150mg as Choline Bitartrate
    [VIT] Choline: 25mg as Choline Citrate
    [VIT] Vitamin B5: 37.8mg as Calcium D-Pantothenate
    [VIT] Vitamin B5: 25mg as Pantethine
    [VIT] Vitamin B6: 74.6mg as Pyridoxal-5'-Phosphate
    [VIT] Biotin: 175mcg
    [VIT] Vitamin B9: 400mcg as Quatrefolic - Folate (as (6S)-5-Methylfolate, glucosamine salt)
    [VIT] Vitamin B9: 600mcg as Metafolin - Folate (as Calcium Folinate / calcium L-5-methyltretrahydrofolate)
    [VIT] PABA: 25mg Para Amino Benzoic Acid (folic acid precursor)
    [VIT] Vitamin B12: 375mcg as Adenosylcobalamin
    [VIT] Vitamin B12: 3125mcg as Methylcobalamin

    [AMINO-ACID] Trimethylglycine (TMG): 1950mg
    [AMINO-ACID] Creatine Monohydrate: 6g
    [AMINO-ACID] L-Glutamine: 30g
    [AMINO-ACID] Taurine: 1500mg
    [AMINO-ACID] N-Acetyl-Cysteine (NAC): 1500mg

    [OTHER] Calcium-D-Glucarate: 1000mg
    [OTHER] Organic Ashwagandha Extract 5%: 600mg
    [OTHER] raw honey: 16g
    =======================================================================

    I also have green, mushy stools (not full diarrhea most days, but they are not formed, and become a mushy ball in the toilet), so I am trying to see what triggers it (sometime I was able to have proper brown formed stools for some days) that's why I am not taking any vitamin C or high-dose Inositol, just because they can cause diarrhea. Magnesium is NOT the problem, I already tested that I did have perfectly formed stools for some days even with this much magnesium. But even a teaspoon of salt in water or 360mg potassium as citrate makes my stool way more mushy (potassium gave me severe diarrhea).

    I am looking for advice what to do about my SNPs, what to adjust in my supplementation, as so far I had not much success in treating my anxiety, OCD and stress, although many of the supplements I introduced only recently.

    I urine-tested for very mild, doubtful pyroluria. Based on symptoms described in Dr. Walsh book "Nutrient Power" I suspect I am undermethylated, likely low-serotonin.

    If anyone has any suggestions what might adjust in my supplementation, in relevance to my genetic mutations. Also if some of the supplements should be moved to a different time - like take them on empty stomach instead of with food (or vice versa).
     
  2. drob31

    drob31 Senior Member

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    You're compound heterozygous MTHFR, as I am sure you know. I have the same mutation here. Clearly methylfolate would be a concern.

    What is your diet like? How about exercise? Those two would be huge factors if you don't have CFS.

    It sounds like you have high cortisol levels though.
     
  3. Omega Terus

    Omega Terus

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    I just started reading everything possible about MTHFR, and it all seems very complicated, and confusing, it will take me days or weeks of learning to figure out, for now I am taking 1000 mcg 5-MTHF daily, and also eating quite some leafy greens, so my total daily folate is even higher. Anything else I should do about my MTHFR mutations?

    My diet is pretty much paleo/bulletproof. Grass-fed beef and lamb, fish, lots of ghee, some coconut oil, olive oil with romaine lettuce, spinach and lots of leafy greens every day, celery, sweet potato, carrots, broccoli, oh, and tons of avocados, plus other fruits. That's pretty much all what I eat.

    Currently not drinking coffee, to figure out is is triggering my mushy stool, but often I was drinking Bulletproof Coffee with ghee and caprylic acid for breakfast. Plus avocados. Eggs, but not right now (just to test if they inflame my gut and trigger mushy stool).

    I eat around 2500-3000 kcal, with roughly 65% of my calories coming from fat (all from meat, fish, ghee, avocado, olive oil, coconut), 20% from protein (grass-fed beef and lamb, wild fish, some eggs, sometimes grass-fed whey protein) and 15% from carbs (all from sweet potato, other root vegetables, broccoli, leafy greens, fruits).

    Currently no exercise, but last year I was going to the gym once-twice a week for weightlifting (didn't make any difference in my mental state). But I will start going again anyway.

    I take a ton of supplements, and have a very clean diet, but so far hardly anything makes any difference for my anxiety/stress, besides: sunshine, forest, quiet environment. Oh, and I have social anxiety when being around more then 1 person, and inability to read and express emotions, but that's probably the pyroluria. I tested Hemopyrrollactamcomplex 0.80262 µmol/24 hr with http://www.hputest.nl/ with lab range 0.6 - 0.85 µmol/24 hr meaning "HPU weak, doubtful" and 0.85-1.4 µmol/24 hr "HPU present, light positive".
     
  4. Oci

    Oci Senior Member

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    This is just an idea based on my experience. I was taking a lot of supplements too and experiencing brain fog, fatigue and other symptoms. I found that the number of supplements increased seemingly exponentially over a period of time. I would read about a new supp online or my Integrative doc would suggest something and I'd add it on. Surely it would make me feel better and more energetic.

    Last visit with him, he suggested I just stop all supplements! This suited me very well. Why should I need so many supplements?! Do I want to spend this amount of money on supps? Just what am I doing? Within a day I felt a whole lot better! My doc suggested after a period of time that I introduce a few of the supps back in.....slowly and really observing results. To compensate for any possible missing nutrients, I am focusing on a high nutrient diet.

    As for Snps...the ones tested are a small percentage of the total we have. There are likely many more that are compensating for ones that we are may have. Much more is unknown than is known about snps. I have come to the conclusion that knowledge of our snps can help us a bit but much more depends on diet, lifestyle and stress management. It is interesting to me that Ben Lynch does NOT take supplements continually for his variant snps but does on depending on need and circumstances. It is Amy Yasko that has people take a million and one supps.

    I am also focusing on enjoying life which reduces anxiety and stress. Exercise too is a great idea.

    Given the very great effect of the microbiome on mood, have you had a CDSA (poop test) done to identify gut bugs? You might really benefit from stopping all supps for a washout period and then have a number of tests done to identify your areas of need. Yes, they are expensive but so are years of supps!

    Good luck!

    Just a suggestion!
     
    Wayne and Gondwanaland like this.
  5. Omega Terus

    Omega Terus

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    I plan on stopping all supplements for 3 days in December and doing most of the tests from http://europeanlaboratory.nl/ as well as NutrEval and Spectracell, and then adjusting the dosages up/down depending on the level in the body.

    Almost all of the supplements I am taking are substances which exist in diet, just not in high enough amounts. Regarding minerals, our soils are depleted, and its impossible to consume enough minerals for optimal functioning with food, so I am just compensating for over-exploited soil with my minerals, nor for my SNPs. As you noticed most of my supplements are minerals. From all the lab tests I already did, most mineral levels came borderline low (except Calcium).

    I will also do a Genova GI Effects stool test.

    Also most of them I have introduced quite recently (as in weeks), so their effects might not have yet kicked in.

    What I want to do is to take some doses of most minerals and vitamins at the same constant dosage for a few weeks now, before the lab testing in December, then stop for a 3-day "washout" and do all the tests, and then see what is high, what is low and readjust.

    What I am trying to do before the tests, is to make be best guess as what dosage of each vitamin/mineral I might need, and then use the lab tests only for readjustment, and checking their impact on my biochemistry. Otherwise I would need to do all the tests twice - once before taking supplements, and then again after 3 months of taking supplements to check their impact, so I want to avoid that because of the cost, and only do lab tests after 3 months of supplementation.
     
  6. caledonia

    caledonia

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    Cincinnati, OH, USA
    Wow that is a lot of supplements. Overall, your plan sounds good to me.

    My other suggestion would be to get a Doctors Data Toxic and Essential Elements hair test then interpret this via Andrew Cutler's counting rules to check for mercury or other toxic metals. The blood test for metals on the Nutreval will only detect current exposures, not past exposures.

    More info on Cutler’s protocol is available here:
    http://www.livingnetwork.co.za/chelationnetwork/chelation-the-andy-cutler-protocol/

    This is the correct hair test to get for the Cutler protocol (ironically, the cheapest from Yasko):
    http://www.holisticheal.com/hair-elements-test-kit.html

    When you receive it, ignore Yasko’s and Doctors Data’s comments and instead submit it to the Frequent Dose Chelation Yahoo Group for interpretation.
    https://groups.yahoo.com/neo/groups/frequent-dose-chelation/info
     
  7. Omega Terus

    Omega Terus

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    Thanks Caledonia. I already did a hair test with Trace Elements, twice. Most of the minerals (except Calcium) where low, some super-low, so based on that I started supplementing Molybdenum and Lithium which where almost non-existent. Also low potassium, but 2x500mg potassium citrate a day (360mg total K) gave me watery diarrhea, so I'll try again with a much smaller dose later.

    So anyway, most of my minerals where on the low side, and the toxic ones too:

    As: 0.006 mg%
    Be: 0.001 mg%
    Hg: 0.02 mg%
    Cd: 0.001 mg%
    Pb: 0.1 mg%
    Al: 0.3 mg%

    By the lab ranges 0.02 mg% Hg is regarded as low, and I didn't think it could be an issue, but maybe I am wrong?

    In December I plan on sending my hair from the same sample to Trace Elements, ARL, and I can also add Doctors Data too - to check if the results will be similar, because I read some accusations and a report that one sample sent to many different labs got completely different results.

    Would you modify anything in the amounts of vitamins, for the period before the testing? For about 10 weeks before the testing I would like to keep the supplementation constant, and not changing anything, so the tests are relative to that supplementation regime, and I know from what level to increase/decrease each one. Is 3 days supplement-free before the blood tests enough, or would you give it a bit more time? I think too much time off before the tests is also not good, but how much is too much?

    I am thinking of ditching the Taurine and NAC, because of CBS mutation, but on the other hand would like to improve glutathione. I am confused about these, and the whole CBS/sulfate/sulfite thing.
     
  8. Omega Terus

    Omega Terus

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    OK, now I read the moriam page, and the counting rules, and I see that low Hg mg% means nothing, and reading the "counting rules" I see that if lot of hair minerals in the low levels or completely out of lab range, can mean abnormal mineral transport. Interesting, this opens up other possibilities, I'll read more on this.
     
  9. TheChosenOne

    TheChosenOne Senior Member

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    Can you post your hair test? Did you do the counting procedure as suggested by Cutler?
    You cannot measure mercury exposure with a hair test if you have methylation problems.

    I think you are taking too much supplements. Mabye it's a good idea to start with just a few that work really well.
     
  10. Omega Terus

    Omega Terus

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    Here is the TEI result attached. Its in polish, but the element symbols are the same.

    Is there a version for the counting procedure for TEI results, as the number of elements and ranges are different?

    "Too much supplements" is not really specific, and when you look at the list it may seem large, but in fact what I am taking is only what would be in a multimineral-multivitamin pill, plus just:

    L-Glutamine (for leaky gut)
    Calcium-D-Glucarate (for estrogen elimination)
    Creatine Monohydrate
    which I take for reasons unrelated to the mental problems,

    so that leaves just 4 which are related to the issues in the subject:

    Taurine
    N-Acetyl-Cysteine
    Trimethylglycine
    Ashwagandha Extract

    Well, and the high dose P-5-P but that's because of pyroluria.

    I could get rid of Taurine, NAC and TMG, but really should I, and if, then precisely why?

    There is no supplement which "works really well". If I have many deficiencies, only many supplements in synergy will have an effect, not one or the other in isolation.

    I started NAC to increase my GSH, and TMG because I am likely undermethylated. I am just taking them for about 2 weeks now.
     

    Attached Files:

  11. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    You'll find a link to Methylation for Dummies in my signature. Also, Caledonia has many beginner resources for methylation.

    You might benefit by increasing the supps for pyroluria, any or all of them, but one at a time: zinc, p5p, selenium, manganese, molybdenum.

    My anxiety had big improvements when I stopped gluten and dairy. Later w/ pyroluria supps. And again, the remainder of it relieved when my adrenals were no longer stressed, following an intense detox. good luck.
     
    Wayne likes this.
  12. Omega Terus

    Omega Terus

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    Trying to apply the counting rules is difficult because the ranges are different, and I am not sure where is the 50% mark on my test, but:

    STEP ONE:
    Above 50%: Ca, Sr
    Above 50% only if using Doctors Data ranges: Na, Cr
    Somewhere around 50% mark, not sure if above or not: S

    So that would be max 5, which could be matching the rule.

    STEP TWO:
    Li - definitely red-low
    Mo - maybe
    Co, Ge - low, but not enough I think (no idea where the red mark is numerically)

    So I don't think it matches the rule.

    STEP THREE:

    14 minerals (B, Rb, Tl, Fe, W, Ni, Zr, Ba, Mn, Mg, V, P, Sn, Cr, Zn, Na, Sr, Ti, S)
    are within the reference range of TEI, so theoretically it doesn't match the rule.

    So its kind of doubtful mercury is an issue, what do you think?
     
  13. drob31

    drob31 Senior Member

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    Creatine will elevate your levels of DHT drastically which could explain the hair growth and other androgen related symptoms.
     
  14. Omega Terus

    Omega Terus

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    But, I am using it because of: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/
    Although not sure if it gives me much benefit, as I eat a lot of meat. What lab tests I could to see how creatine is affecting me?

    I would like to only take supplements that I can measure via lab tests (blood, urine, etc) how it is affecting the levels of substances in my body, and if I am not overdoing it. That's why in December I will measure ALL minerals and vitamins in my blood with http://europeanlaboratory.nl/ which measures many minerals intracellular and/or whole blood. I know that serum levels are often worthless.
     
  15. TheChosenOne

    TheChosenOne Senior Member

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    You can change TMG for phosphatidylcholine. Your body will make TMG with it. You also save SAMe, because about 1/3 of it is converted to phosphatidylcholine.
    I'd start basic if I was you and check the guide made by Caladonia.

    NAC and taurine are high in sulfur which can cause a problem in certain individuals. NAC promotes the production of glutathione which is (if I'm right) not so good in the beginning of the protocol.

    The ranges for a hair test are gender and age specific, so it's a bit hard to compare yours with the one from Doctor's Data. The text on the left is 'reference range'. What percentage it that? 16 or 2.5 or something else? And what kind of units do they use? Doctor's Data uses mcg/g.
    You look like you have a lot of bars to the left (low). I've made a blogpost about how you need to interpret the counting rules: http://theinternetz.org/2015/05/how-to-read-a-hair-test/
    You'll see my hair test as an example. It includes a form (link at the bottom) where you can enter your numbers and then it calculates the chance that you have a certain result. It can work with an arbitrary amount of elements.
     
  16. Omega Terus

    Omega Terus

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    @TheChosenOne I don't know what percentile is the reference range, but because the ranges are generally similar to Doctor's Data (which are 16% percentile), let's assume for now that its 16% too.

    The units are mg%, so multiply by 10 to obtain mcg/g.

    For easier overview, I've put together a table as described on the bottom of http://home.earthlink.net/~moriam/HOW_TO_hair_test.html#how_to_post
    But because there is no red, yellow, green, I've put there percentages of the reference range, with 0% meaning the value is exactly at the lower end of the reference range, and 100% meaning the value is at the top end of the reference range. Negative value means now much below the low end of the reference range is the result.

    So if we assume the reference range is 16% percentile-based, then everything between 0% and 100% is "green".

    Be aware that some minerals have a mark "<<" which means that the value is below the margin of error, even though some of these values are equal to the lower end of the reference range.

    So I would assume that Lithium and Molybdenum are in red, Potassium, Copper, Selenium, Cobalt, Germanium are in yellow, and the rest of "ESSENTIAL AND OTHER ELEMENTS" are in green.

    So I would assume:

    Total amount: 22
    Lowest amount of bars to one side: 1
    Amount of bars in the red area: 2
    Amount of bars in the green area: 15

    Is there anything that can be said from this data and the below table?

    The units below are mcg/g (I multiplied the TEI mg% values by 10).

    POTENTIALLY TOXIC ELEMENTS
    element result ref range percentage
    ===============================================
    aluminum 3 < 18 17% <<
    antimony not measured
    arsenic 0.06 < 0.20 30%
    beryllium 0.01 < 0.01 100% <<
    bismuth 0.02 < 3.90 1% <<
    cadmium 0.01 < 0.14 7% <<
    lead 1 < 3 33% <<
    mercury 0.2 < 1.8 11%
    platinum 0.01 < 0.02 50% <<
    thallium 0.005 < 0.06 8% <<
    thorium not measured
    uranium 0.007 < 0.170 4%
    nickel 0.1 < 1.0 10%
    silver not measured
    tin 0.1 < 0.3 33% <<
    titanium 0.9 < 2.0 45%

    ESSENTIAL AND OTHER ELEMENTS
    element result ref range percentage
    ============================================================
    Calcium 890 220-970 89%
    Magnesium 34 20-110 16%
    Sodium 160 40-360 38%
    Potassium 10 20-240 -5%
    Copper 9 9-39 0%
    Zinc 140 100-210 36%
    Manganese 0.25 0.1-1.3 13%
    Chromium 0.4 0.2-0.8 33%
    Vanadium 0.04 0.02-0.14 17%
    Molybdenum 0.01 0.03-0.08 -40%
    Boron 0.5 0.2-9.1 3%
    Iodine not measured
    Lithium 0.01 0.01-0.06 0% <<
    Phosphorus 140 110-200 33%
    Selenium 0.3 0.3-1.8 0%
    Strontium 2.3 0.3-5.0 43%
    Sulfur 43760 35460-53360 46%
    Barium 0.3 0.0-2.6 12%
    Cobalt 0.01 0.01-0.03 0%
    Iron 6 5-16 9%
    Germanium 0.06 0.06-0.11 0%
    Rubidium 0.007 0.000-0.190 4%
    Zirconium 0.1 0.0-0.9 11%
     
    Last edited: Oct 7, 2015
  17. TheChosenOne

    TheChosenOne Senior Member

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    You have to look at the cumulative chance, which is 5.48362731934e-06 (= 0.0005%) for the one bar to the right. This is the chance that a random person would have such a hair test. This means deranged mineral transport with almost 100% certainty (according to this method).
    Just one more question. What does the percentages that you get mean? At Doctor's Data, you are compared with the rest of the population (so your percentage is where you stand compared to the rest of the hair samples they get). Is this also the case in your hair test? Because the ranges on my hair test are very different.
     
  18. Omega Terus

    Omega Terus

    Messages:
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    Assuming the analysis is correct, an in fact I have "deranged mineral transport", does that in itself mean I have brain mercury toxicity and enough proof to warrant chelating, or are there any other tests I could perform to find out for sure? Of course I will do another hair test with DDI anyway, but that will take some weeks to get a result, and maybe I can start doing other things simultaneously. Like other tests, or very low dose chelation.

    The percentages above are calculated by myself with a spreadsheet, taking the measurement value and calculating where it lies between the bottom and top ends of the reference range given by Trace Elements, Inc.

    About the reference ranges, all I know is this text from http://www.traceelements.com/docs/PatientReport.pdf
    And http://www.traceelements.com/LabServices/QualityAssurance.aspx
    Does that answer the question?
     
  19. Omega Terus

    Omega Terus

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    Quitting gluten, grains, sugar helped my ADHD, which I had more of before, but my OCD where I get obsessive thoughts and get stuck in my mind on one thing is still there. Although maybe less, because before I was wasting time aligning cans in supermarket when I went shopping, and bought everything in multiples of 3, I don't do these things any more, but when I get stuck in my mind about some thought, idea, I can't let it go and spend whole day on it even if I had other important things to do.

    Also anxiety is still high in the form that before I start doing anything, I spend hours worrying about "did I think about everything I needed to think about today", if I have something planned for the afternoon, I often can't absolutely get anything done in the morning, because of worrying that I will forget to stop doing what I am doing and miss the thing I planned.

    Now the only dairy I eat is ghee.

    Why should I increase the pyroluria supplements, if they are already quite high, and my pyroluria is VERY mild/doubtful? I repeated the urine test three times with two labs, and the results all came more or less around the boundary of the reference range of what is considered "normal" and "pyroluric".

    Biolab.co.uk Kryptopyrroles (not very accurate) test came back at 0.07 AU, where they define pyroluria to begin at 0.08 AU and above.

    KEAC HPU-test 24h urine Total amount of HPL excreted: 0.80262 μmol/24 hr. where the lab reference scale is:

    <0.6 HPU absent
    0.6-0.85 HPU weak, doubtful
    0.85-1.4 HPU present, light positive
    >1.4 HPU present, positive

    KEAC KPU Total Kryptopyrroles Urine 24 hour:
    0.08 Units (which is translated to 25.0 μg/dl KPU)
    This was a 24h urine test, so their lab reference range is < 0.125 Units/24 hour
    Although this test may be undervalued, as the sample was kept 4 days ice (probably around 0-4 deg C), and KPU disintegrates quite quickly (no idea how quickly at these temperatures). HPL complex measured in the previous test is more stable.

    So all three results are quite low, too low to definitely confirm pyroluria, just leaving the possibility its a factor, although not very strong. How high where your urine test results if you did any?
     
  20. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    Ive not tested. I only suggested increasing in case there was a very simple fix.

    There's a product you might consider. It's one of 2 things I used I was convinced to pay a premium for, and am so glad I did. Neuroprotek was designed by pharmacologist and mast cell expert Dr. Theoharides. It helps stop the brain storm in autistim. For me, it did the same. When I'd done everything I could see I needed to do in my healing process, I was still aware of enormous chatter in my head. This really chilled it. And since my efforts of this year, I'm no longer needing them. Which is really to the point, of trying to see if you can get to the missing co-factors.

    A vid about what Theoharides believes is going on in the brain, and a 15 minute one of him discussing Neuroprotek.

    ‪‘Brain Allergy’ and ASD - T. Theoharides, MD, PhD‬
    https://youtube.com/watch?feature=player_detailpage&v=9QbZp3WcC1Q


    Neuroprotek http://.youtube.com/watch?feature=player_detailpage&v=pNQsK9PQL3c
     
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