1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Cognitive testing causes mental exhaustion lasting days
Simon McGrath takes a brief look at a recent paper that reveals some of the most powerful evidence of cognitive problems in people with ME/CFS to date...
Discuss the article on the Forums.

I have just bought the 23.me test

Discussion in 'General ME/CFS Discussion' started by Lisa6235, Sep 25, 2013.

  1. Hi everyone

    I have just finally purchased this test after saving all month. I am wondering if anyone has any feedback on this test and has it helped you.

    I have a lot going on with hypothyroidism low ferritin and extremley low iron but can not tolerate iron due to hallucinations and high anxiety and can't tolerate any supplementation at all. . the list is endless so i wont bore you all again and i just wanted to know if the test gave you a good starting point as I can not afford any more tests now for at least 3months.

    Thanks
    Lisa x
    aimossy likes this.
  2. Helen

    Helen Senior Member

    Messages:
    304
    Likes:
    193
    Sweden
    Hi Lisa,

    I think you have made a real good choice when you bought the test.
    Use the program on www.geneticgenie.com when you get the mail from 23andme with your results. Then you will be able to see if you are prone to a lack of bioactive folate (with MTHFR mutations). You will also be able to see if you are prone to a vitamin B12 deficiency caused by mutations in the MTRR/MTR genes (or SNP´s).

    These two groups of mutations are the most important to look at when you check for a blocked methylation even if there are more SNP´s that might have an impact .

    A folate and/or vitamin B12 deficiency might decrease your ability to methylate with possible bad consequences for your health. (It is possible to test the methylation too, but it costs a lot more than the gene test).

    If you then find some of these gene defects, the best is to read all what you can about methylation and treatment protocols, and ask questions here where there are lots of helpful and knowledgeable people.

    Your hypothyroidism might be connected to a blocked methylation, or maybe it is autoimmune that is the most common cause. The autoimmune hypothyroidism is for many caused by dental amalgam, or gluten.

    A low ferritin might be caused by a vitamin B12 deficiency. A doctor said to a friend: " without enough B12 the iron will not stay in the body" - or something like that ;-). English isn´t my native language...

    As you can see you will in some weeks be able to see if B12, folates and blocked methylation might be a part of your health problems.

    All the best!

    Helen
    Valentijn and Crux like this.
  3. stridor

    stridor Senior Member

    Messages:
    263
    Likes:
    166
    The test "proved" to my Dr that I had methylation problems as I had predicted with the MTHFR C677T++ result. The TCN2++ and MTRR++ x2 gave the Dr a rationale to increase my mB12 (TCN2++ is called the "frailty gene" and is involved in transport of B12). Daily injections put me back on my feet.
    I think so highly of the test that I bought 3 more kits for sick siblings and will be using the collected results to delve into mitochondrial SNPs. 45% of which are ++ or +-.
    Valentijn, Crux and Helen like this.
  4. Helen

    Helen Senior Member

    Messages:
    304
    Likes:
    193
    Sweden
    @ Lisa,
    I have just read your input about your detox of mercury.

    Another good thing with the 23andme test is that you can check some of the most important genes for mercury detoxification (GSTP1, GSTT1..) Unfortunately I don´t think you can see the GSTM1.

    To check the GST- genes you have to use not only the methylation program in geneticgenie but also the detox.
  5. taniaaust1

    taniaaust1 Senior Member

    Messages:
    6,749
    Likes:
    3,326
    Sth Australia
    I have a double copy of the worst MTHFR polymorphism (found out by a test the dr did), for myself it has been very important to find out I had that as treating it via supplements has helped some (its the only thing which has helped my endurance a bit). I know MTHFR issues is one of the things 23andME tests for.
    ...........

    Im actually right now waiting for my 23andME test results to come back (they said its currently a 4-6 week wait) to see if anything else comes up, Im currently wondering if I have a CBS mutation (as I have nil molybdenum on my hair test). I also want to find out if I have increased breast cancer as my grandma died of two different kinds of breast cancers and her specialist had said my mother and her grandchildren (me) should be getting mammograms yearly from the age of 40 years which Im now over but I dont like the idea of having all that radiation, I'd rather know if Im at more risk by my DNA results.
    Crux likes this.
  6. Valentijn

    Valentijn Activity Level: 3

    Messages:
    4,752
    Likes:
    5,070
    Amersfoort, Netherlands
    23andMe does include GSTM1 (and all of the other glutathione genes I've looked at). 23andMe lists 11 GSTM1 SNPs, 8 of which are somewhat interesting due to having rare versions. Though there's no research into any of them, which is pretty typical, since there's limited corporate interest in detoxing, and SNPs with a rare allele are nearly impossible to research anyhow.

    If 23andMe doesn't show any GSTM1 results for someone, it's probably because the gene is missing in that person. It's not particularly uncommon for that to happen, though can have implications regarding cancer risk and drug impact on the liver. I have GSTM1, but am missing GSTT1 :p
    Helen likes this.
  7. Wow thank you all for your fantastic input. I am hoping it can help me as much as everyone else. Methylation is so complicated so at least I have a starting point

    Hi Helen thanks for your response also, unfortunatey I have tried b12 along with folate but again I get the same reactions. Palps, anxiety and hallucinations I think this is why I am so confused as these supplements are meant to help with methylation. Hopefully the rest will explain why this happens.

    Thank you all for your responses again I really appreciate it

    Thanks

    Rachel
  8. Wow thank you all for your fantastic input. I am hoping it can help me as much as everyone else. Methylation is so complicated so at least I have a starting point

    Hi Helen thanks for your response also, unfortunatey I have tried b12 along with folate but again I get the same reactions. Palps, anxiety and hallucinations I think this is why I am so confused as these supplements are meant to help with methylation. Hopefully the rest will explain why this happens.

    Thank you all for your responses again I really appreciate it

    Thanks

    Rachel
  9. stridor

    stridor Senior Member

    Messages:
    263
    Likes:
    166
    Thank-you for reading my stuff. I have one +- GSTM1 gene. One thing that I did not need 23andme to confirm was my mercury toxicity status. I am a "perfect storm". My genetics might not have been an issue had I been born in Cleansville, No-toxin-vania, but instead I was exposed to mercury before I had time to achieve any degree of neurodevelopment.
    Whatever my genetics, low glutathione production has determined my life. Bipolar symptoms (resolved), ME/CFS. Hyperplastic Polyposis all speak to my low glutathione status. No glutathione = no glutathione-s-transferase regardless of how happy my GST genes are. At least that is how I would interpret this (??)
  10. stridor

    stridor Senior Member

    Messages:
    263
    Likes:
    166
    Lisa6235
    Be interesting to see if you come back COMT++. This enzyme breaks down dopamine and norepinephrine. Too much dopamine is the (ridiculously simplified) explanation for schizophrenia with a symptom-set that includes hallucinations. mB12 in particular can feed this.
    Hydroxocobalamin and magnesium have been mentioned by some as the approach to take. Baby steps with all supplements If you have COMT++.

See more popular forum discussions.

Share This Page