(Some may know me from the POTS forum!). I have a 30 year history of low blood sugar, that showed up in my late 20s. Fastforward to getting POTS in my late 40s, and have lived with it for the last 9 years. At the same time my low blood sugar has intensified, and I have been visiting doctors for both POTS and hypoglycemia. I did my 23andme testing a couple of years ago, and looked through the usual SNPs that are talked about here. Nothing totally unusual, but am heterozygous MTHFR. Every time I read a Pubmed or other scientific article that is related to my health conditions AND mentions some gene, I immediately look up my genetic results on my 23andme results just to make sure nothing is overlooked. This week I looked up GLPR2(glucagon-like peptide receptor) after reading something about blood sugar issues. Anytime I look up where I fall, I always compare it to HapMap-CEU for European ancestry. This time 2 of my SNPs didn't even show up! I was GG on one and AA on another, and they were literally 0.000%. I also had one SNP that was only 0.9%. Does anyone know enough about all this to know if this is significant? I thought it strange that I have the long history of low blood sugar and this gene regulates how your body responds to glucose after eating! Thanks for any help!