LaurieL Hi– I have been reading about MTHFR for sometime now after noticing that tongue tie was related to the mutation. I have been on and off anxiety medicine for a few years. My genetic genie results showed that some of my mutations lead to low production of BH4 which helps promote reproduction of neurotransmitter. I was hoping to supplement with low doses of methyl-folate but it causes me to have terrible headaches and breakouts. Do you think that I could handle Niacinamide to treat the MAO mutation or would my CBS mutation not allow that? I have been reading your replies to others and you see very insightful. Please take a look at mine if you have a chance. Any suggestions of where to begin are much appreciated! I am homozygous for:MTRR A66G BHMT-02 BHMT-04& heterozygous for –MTHFR A1298C COMT V158M COMT H62H VDR Bsm VDR Taq MAO-A R297R BHMT-08 CBS C699T CBS A360AAny advice is appreciated. Thanks so much!!!