I have a fever for the first time in over two years and don't know what to make of this and am open to any and all interpretations. For the last few days I've been feeling extra sick more similar to a flu or mono type feeling. I've had alternating chills/hot, nausea and diarrhea (sorry for TMI ), muscle pain, and just felt very feverish. It is what I call the "Sickly fatigue" which had been eliminated for me thanks to Famvir but for whatever reason is now back. I was supposed to start Valcyte but have NOT started it yet so this is not a factor. I'd stopped checking my temperature a long time ago b/c I have not had a fever in over two years. My temp runs around 97 degrees and even as low as 96. I rarely reach 98 degrees and never 98.7. But today I felt so feverish and sick that I finally checked it and it was 99.2 which is a true fever for me! No one in my household is sick so I did not catch anything from them. This is the sickest I have felt in a very long time. I got very used to the autonomic issues (tachycardia, low blood pressure, shortness of breath, angina type spasms and the inability to create energy and constant PEM.) But I had forgotten what it feels like to have this sickly feeling on top of it and it SUCKS . Is the fact that I now have a fever after two years a good sign that my immune system is kicking back in or a bad sign (or neither?) I am still taking 1.5 grams of Famvir per day. I briefly tried to increase it to 2 grams a day (per my doctor) but had a bad reaction so we lowered it back down. But I never stopped it so I don't see how this could be the causal factor. The only other factor is that I tried Mestinon for one day at 1/8 tablet (to try to raise my BP and help the autonomic issues.) I had an allergic/cholinergic reaction so we stopped it and I never took a second dose. This was three days ago and it seems unlikely to be related IMO. Has this happened to anyone before (no fever for two years and suddenly get a fever!) What does it mean? Even though I may get overwhelmed by the responses, I really want to hear them. Thanks in advance to everyone .