Very new to all this...and overwhelmed. Main problems aredepression and insomnia. Physical energy pretty good. Some brain fog, which improves on Lactulose(NH 3? ). Am taking methyl B12(3 mg, injected), leucoverin and methyl folate. I thought all this was supposed to result in normalizing the methylation cycle in order to create glutathione and be able to detox. But the doctor has also prescribed a glutathione nasal spray. Doesn't that just bypass the whole methylation cycle thing? And that would appear to be good, if the point of all this is to raise glutathione. Is this the point? Or do all the components like the methyl B12, methylfolate etc. have other beneficial functions, which we don't want to shut down via negative feedback loop? So far since starting therapy, I have had dreadful itching,lesions and constipation(hence Lactulose) and have had to take Zyrtec! So much for alternative medicine! Wondering if I should add SAMe--it's supposed to help reduce histamine. Or is that going to mess things up further? My genetic profile is in my signature, if that offers up any clues. Thanks in advance for any insights.