The CBS SNPs tested have very little impact or none at all. They do not cause problems.
We are so young in the process of identifying SNPs that relate to disease that we have no way of knowing what future studies will show.
How so? Yasko's belief is that VDR and COMT are relevant to methylation because they might effect need for methyl donors or intolerance of them. But there's no evidence supporting her belief, and anectdotal data suggests that those VDR and COMT SNPs do not accurately predict a reaction to methyl donors.
Well she predicted my reaction. I had to take an anti-anxiety pill for the first time in a year after starting Meb12 and MeFolate. I don't know if she's right but when a response is predicted out of the millions of possibilities then I start listening. It doesn't mean she is right, but it does mean that I will follow the protocol to see how it goes.
Those VDR and CBS SNPs do pretty much nothing, so wouldn't be affecting your dopamine levels (or anything else, really). It would be far more cost-effective to test blood dopamine levels before starting on a lengthy and over-priced treatment for a problem which might not exist at all. Most lab services offer a catecholamine panel which includes dopamine.
I read every study that mentioned CBS C699T and not one of them mentioned dopamine levels in relation to the snp and methylation. I don't know a lot about snps and what their relationship with health is, but I do know logic and I am pretty sure you cannot prove a negative. So ... you don't think that CBS has any affect on health, and you want to protect people from quack doctors, I get it. But we are so early in the battle to make medicine personal that I think there is not enough knowledge to say anything with total certainty.
+/- would be the most common and normal/balanced version. Doesn't make sense to "treat it".
Unfortunately the concept of methylation has been rather badly abused to support the use of elaborate protocols with no foundation in science or reality. I'd suggest ignoring anything which can be traced back to Yasko, since her claims can be proven wrong or unsubstantiated more often that not.
I have read all of the articles listed on snpedia claiming Yasko is a quack and they only mention her in passing and then not even mentioning her genetic work. So I did a google search of "Yasko quack". The one I did read that talked at length about Yasko, said that she prescribes vitamins with no scientific basis. Well ya, the science of treating your genetics hasn't even gotten started. So no one has any treatment for a SNP yet, right?
I'm not saying she's right but I am willing to give her protocol a ride even though I don't know if it will work. But here is what I do know:
- I have sulfa drug allergies
- I can get extremely ill on luncheon meat and other things with sulfites (but not always)
- My urine has always smelled really strong (like ammonia). Like spray the room after I go strong.
- I have this pain in my back between the shoulder blades which causes me great discomfort. When I am in a flare I can increase the pain by eating beef and I can stop the pain by fasting for 3 days.
- When I was on meb12 and mefolate and woke up with the jittery feeling and started taking my anti-anxiety drugs (after being off for a year or so). Yasko predicted that reaction with my CBS allele.
These are only my realities and they do not prove the science in any way. But I have been noticing that many of the studies that I have been reading on different snps basically are data to associate a specific disease to a specific snp. It is more formal than Yasko's for sure, but she noticed a trend and made a treatment decision based on that trend. If you know of a study that proves that a CBS snp does not cause high levels of ammonia, I will drop my protein-limiting diet (which I have not had the energy to start yet) in a hearbeat.
Maybe I am wrong and maybe not. I appreciate your response and have noticed that you are very helpful to folks on this board and I thank you.
