Thanks for posting your story, @samtemp. I have never tried any ozone therapy other than my transdermal ozone water method, so unfortunately I cannot compare its efficacy (in terms of my subjective sense of how it helps my symptoms) to other methods. I came up with my transdermal method after hearing about ozone gas applied via a body bag that covers you whole body, and hoped that transdermal ozonated water would get similar results as a body bag. But if anyone like yourself that has experience with other methods would like to try this transdermal ozone water approach, then you would be in a position to subjectively judge its efficacy against other methods. It would certainly be much cheaper and much more convenient to administer ozone at home by this transdermal method. Note also that that in ozone autohemotherapy, although you are applying 80 gamma ozone to around 100 ml of blood extracted from the body, there are around 50 liters of water in the body in total, so once this treated blood is returned to the body, the ozone in it gets diluted down by a factor of 50,000 / 100 = 500 times. Sounds like you had a great improvement from ozone. Would you be able to quantify this improvement more precisely by saying where you were on the ME/CFS scale of Very Severe – Severe – Moderate – Mild – Remission before you had your ozone treatments, and where you are on the scale afterwards. Were you able to achieve a 1-level improvement on this scale (eg, move from moderate to mild, or move from mild to remission)? Or did ozone not make much overall improvement to your ME/CFS, but just helped particular symptoms such as pain or sleep? It is widely believed that ozone therapy will kill pathogens in the blood and tissues, just like the way bleach kills microbes. However, if you read any scientific source, you will find that the levels of ozone used in such therapies are far too low to have any direct killing effect on pathogens in your body. It's possible that ozone might stimulate the immune system in a way that helps fight pathogens; that however is an indirect means of killing pathogens. But ozone may offer other benefits not related to pathogens.