I just watched this Shoemaker video on treating Borrelia and detoxifying neurotoxins: http://www.betterhealthguy.com/dr-ritchie-shoemaker-video-on-lyme It seems to make sense to detoxify neurotoxins while doing antibiotics and thus perhaps reduce a herxheimer reaction. However while researching, I saw this, which basically says all this is nonsense: Excerpt: "Until the existence of Lyme neurotoxins is proven (it shouldn’t be so hard to find them in a culture broth), we should not risk what remains of our health and spend time, effort and money on trying to “detox” them, because the “detoxifiers” and “toxin binders” such as Cholestyramine (Questran) have never proven their value in any randomized, double-blind, placebo-controlled, peer-reviewed, reproducible trial but they do have very serious potential side effects, including cancer. Those binders bind important nutrients as well, weakening the immune system. “Detoxing” (AKA the ethereal “body cleansing”) distracts from the real issue: How to kill the Lyme spirochetes more effectively and how to prevent an extreme immune response to the Bb bacteria/dieoff damaging our tissues." http://owndoc.com/lyme/lyme-neurotoxin-detoxing-nonsense/ Since I'm about to start treatment for Gram Negative Bacteria, I'm wondering where people who have researched this stand and/or if anyone has had experience taking Cholestyramine and antibiotics for Borrelia or co-infections and their experience.