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Hypovolemia as a Model of Space Flight (NASA)

Discussion in 'Problems Standing: Orthostatic Intolerance; POTS' started by voner, Nov 28, 2015.

  1. voner

    voner Senior Member

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    I came across this little tidbit at a NASA site and I just thought I'd post this to see if it's stimulated any thoughts in relation to our orthostatic intolerance. orthostatic intolerance in astronauts is a very well-known phenomenon, but I did not know they had been studying hypovolemia.

    I did not find the text of the study, I just found this description of the NASA site:


    This study has demonstrated that plasma volume loss contributes to, but does not fully explain, space flight-induced orthostatic intolerance and decreased cardiac function. Thus, pharmacologically-induced plasma volume loss may be an acceptable tool to test the efficacy of some countermeasures against orthostatic intolerance (i.e. compression garments). Hypovolemia may be an appropriate alternative model to a more costly and time-consuming analog (i.e. bed rest) in certain circumstances.

    The testing of pharmacological countermeasures to orthostatic intolerance, original objectives of this project, was canceled prior to the start of data collection.


    here is the website.

    http://humanresearchroadmap.nasa.gov/Tasks/task.aspx?i=939
     
    Sidereal and Sean like this.

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