Dr. Ron Davis applied for an NIH grant and was rejected on the basis that his research was not hypothesis testing. His rebuttal was that ME/CFS is still in an an observational state. I agree with Dr. Davis. The research is so weak at this point, amounting to only keyholes of information into biological anomalies. I have two questions: 1) If Dr. Davis were to make an hypothesis, what could be proposed? What research would support this proposed hypothesis? 2) What was the hypothesis formed to fund the PACE trial (although the UK may have different criteria for funding) or other BPS studies, and how was that hypothesis supported?