I take Venlafaxine which causes a lot of muscle twitching. I get jolts which I feel but also a lot of twitching that I can't feel but can see when I look at my calf muscles - this is going constantly 24 hours a day. I have also been experiencing sleep paralysis - not the weird dream kind where people feel there is someone sitting on their chest - but rather when I wake it takes me a good half hour before I can move - and the feeling of tired / relaxed muscles stays with me all day. I understand that the chemicals responsible for muscles relaxing when we sleep is GABA and Glycine - this effects pretty much everyone - but it seems for me my muscles are staying relaxed when I am awake. So my hypothesis is that because my legs are twitching constantly 24 hours my brain is pumping out much more GABA and glycine to try and counter the fact that my muscles are twitching - i.e. my brain is trying to calm the twitching. This in turn is resulting in the sleep paralysis and the constant feeling of tiredness is a combination of the constant twitching depleting energy and the GABA/Glycine which is relaxing my muscles. Has anyone thought about anything like this before? I am not diagnosed CFS I am borderline on symptoms. Plus I don't know how common restless legs is with CFS patients or how often they experience sleep paralysis. Could an imbalance in GABA/Glycine be a potential cause or exacerbator of chronic fatigue and has there been any research on this?