Hey guys, does anyone know if there's a relationship between (hyper)eosinophilia and Mast cell disorders? I've been having eosinophilia for the last 6 months and i believe i have some kind of mast cell disorder. Last month i felt fine for a few days so i did a CBC to check if anything changed and surely the eosinophilic count was much lower. A few days later i started to feel bad again, did another CBC and eosinophils were up again. The last month my symptoms have become worse, i lost 4.5kg in 3 weeks (and i'm already severly underweight)!, i can feel the inflammation in my skin, my ears, nose and cheeks flush a bit. The attacks always happen after eating a meal and last from 1 to 3 hours. Heat seems to aggravate and trigger it as well. Other symptoms i'm experiencing: GI inflammation Joint pain Flushing Anxiety / panic attack after eating Fatigue Diahhrea Conjuncvitis / dry eyes Muscle wasting Just the feeling as if i'm going crazy / depersonalization, this comes and goes. I'm due for a colonoscopy next week and the GI doc wants to take some biopsies of the Ileum (nodular lymphoid hyperplasia) and colon (colitis, proctitis) . Should i ask them to check for mast cells in the biopsies if possible? I know about the tryptase and urinary histamine test. Which other tests can i do as well to check for mast cell disorder?