Please – I need a quick answer! I am homozygous C677T. (No further testing has yet been done.) I could not take the compounded methylB12/folate injections that worked for my doctor’s other patients. She said I’m the first to not respond well to that, so she was puzzled. We then tried the sublingual Active B12/Folate from ProThera. Again, it made me worse. After a few months of doing nothing, my doctor called a couple of days ago to tell me she ordered compounded hydroxo injections, and I have them in my freezer right now. But I have read recently that it can bring on depression – something I already struggle with – if nitric oxide levels are already low. Beacuse I already have terrible fatigue (mental and physical), brain fog, weakness, lethargy, irritability and more, I’m scared to try these new injections! I also saw somewhere that Vit C should be avoided – but the only thing (and very recently discovered) that has helped my chronic fatigue has been Dr. Wilson’s Super Adrenal Stress Formula, which is loaded with Vit C! ( I just can't stop the one thing that seems to be helping.) My questions are: 1) If I react negatively to the hydroxo injection, what is the quick fix? I know niacin helps pull you out of the trouble from methylcobalamin, but what will pull someone out of a depression reaction to the hydroxocobalamin? 2) Will I counteract the injection by taking the adrenal supplement with high Vit C?