Phoenix Rising tells QMUL: release the PACE trial data
Mark Berry, Acting CEO of Phoenix Rising, presents the Board of Directors’ open letter to Queen Mary University of London (QMUL) urging them to release the PACE trial data, and hopes that other non-UK organisations will join British charities in the same request...
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Human herpesvirus 6 infection impairs Toll-like receptor signaling

Discussion in 'Other Health News and Research' started by leelaplay, May 19, 2010.

  1. leelaplay

    leelaplay member

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    kelly to CO-CURE May 16

    Virol J. 2010 May 10;7(1):91. [Epub ahead of print] (virology link)

    *Human herpesvirus 6 infection impairs Toll-like receptor signaling**.* (ncbi link)

    Murakami Y, Tanimoto K, Fujiwara H, An J, Suemori K, Ochi T, Hasegawa H, Yasukawa M.

    *Abstract*

    ABSTRACT: Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent
    cells, including T lymphocytes, monocytes/macrophages, and dendritic cells
    (DCs) suggesting that HHV-6 infection affects the immunosurveillance system.
    Toll-like receptor (TLR) system plays an important role in innate immunity
    against various pathogens.

    In the present study, we investigated the effect of HHV-6 infection on the
    expression and intracellular signaling of TLRs in DCs.

    Although expression levels of TLRs were not decreased or slightly elevated
    following HHV-6 infection, the amounts of cytokines produced following
    stimulation with ligands for TLRs appeared to be dramatically decreased in
    HHV-6-infected DCs as compared to mock-infected DCs. Similarly,
    phosphorylation levels of TAK-1, IkB kinase, and IkB-a following stimulation
    of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4,
    appeared to be decreased.

    These data show that HHV-6 impairs intracellular signaling through TLRs
    indicating the novel mechanism of HHV-6-mediated immunomodulation.

    http://www.virologyj.com/content/7/1/91
     

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