International ME/CFS and FM Awareness Day is May 12: The World Will Know
Did you know that May 12 belongs to us? Lots of us are aware of this. We share the buzz on it amongst ourselves. We add blue ribbons to profile pictures. We raise our voices, join our hands, mount the few podiums available to us and tug at the sleeve of the rest of the world.
Discuss the article on the Forums.

Human herpesvirus 6 infection impairs Toll-like receptor signaling

Discussion in 'Other Health News and Research' started by shrewsbury, May 19, 2010.

  1. shrewsbury

    shrewsbury member

    Messages:
    1,540
    Likes:
    59
    kelly to CO-CURE May 16

    Virol J. 2010 May 10;7(1):91. [Epub ahead of print] (virology link)

    *Human herpesvirus 6 infection impairs Toll-like receptor signaling**.* (ncbi link)

    Murakami Y, Tanimoto K, Fujiwara H, An J, Suemori K, Ochi T, Hasegawa H, Yasukawa M.

    *Abstract*

    ABSTRACT: Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent
    cells, including T lymphocytes, monocytes/macrophages, and dendritic cells
    (DCs) suggesting that HHV-6 infection affects the immunosurveillance system.
    Toll-like receptor (TLR) system plays an important role in innate immunity
    against various pathogens.

    In the present study, we investigated the effect of HHV-6 infection on the
    expression and intracellular signaling of TLRs in DCs.

    Although expression levels of TLRs were not decreased or slightly elevated
    following HHV-6 infection, the amounts of cytokines produced following
    stimulation with ligands for TLRs appeared to be dramatically decreased in
    HHV-6-infected DCs as compared to mock-infected DCs. Similarly,
    phosphorylation levels of TAK-1, IkB kinase, and IkB-a following stimulation
    of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4,
    appeared to be decreased.

    These data show that HHV-6 impairs intracellular signaling through TLRs
    indicating the novel mechanism of HHV-6-mediated immunomodulation.

    http://www.virologyj.com/content/7/1/91
     

See more popular forum discussions.

Share This Page