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Human herpesvirus 6 infection impairs Toll-like receptor signaling

Discussion in 'Other Health News and Research' started by shrewsbury, May 19, 2010.

  1. shrewsbury

    shrewsbury member

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    kelly to CO-CURE May 16

    Virol J. 2010 May 10;7(1):91. [Epub ahead of print] (virology link)

    *Human herpesvirus 6 infection impairs Toll-like receptor signaling**.* (ncbi link)

    Murakami Y, Tanimoto K, Fujiwara H, An J, Suemori K, Ochi T, Hasegawa H, Yasukawa M.

    *Abstract*

    ABSTRACT: Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent
    cells, including T lymphocytes, monocytes/macrophages, and dendritic cells
    (DCs) suggesting that HHV-6 infection affects the immunosurveillance system.
    Toll-like receptor (TLR) system plays an important role in innate immunity
    against various pathogens.

    In the present study, we investigated the effect of HHV-6 infection on the
    expression and intracellular signaling of TLRs in DCs.

    Although expression levels of TLRs were not decreased or slightly elevated
    following HHV-6 infection, the amounts of cytokines produced following
    stimulation with ligands for TLRs appeared to be dramatically decreased in
    HHV-6-infected DCs as compared to mock-infected DCs. Similarly,
    phosphorylation levels of TAK-1, IkB kinase, and IkB-a following stimulation
    of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4,
    appeared to be decreased.

    These data show that HHV-6 impairs intracellular signaling through TLRs
    indicating the novel mechanism of HHV-6-mediated immunomodulation.

    http://www.virologyj.com/content/7/1/91

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