Right, mirtazapine lowers cortisol. I think we can not say anything in general about our diurnal cortisol. Some have low (flat) throughout the day and night, whereas other others might have a skewed rhythm, with too low in morning and too high at night. Mine was flat all the way both times I tested. Strangely though, I had a lot of (physical) energy on mirtazapine, although mentally it felt like I was lobotimized. Perhaps because it enhances NE release.