Yes, shame isnt it? For me i had to actually have some improvement before i could take the coq10 - reacted weirdly to it, but now have been on it for about a month. I do daily MB12 injections and they have been the best thing i have done by far. I had to half the prescribed dose as it made me feel nasty - excitotoxicity type symptoms, but now i feel i cant live withpout it. I think for me it gives me a good antioxidant 'cover'. I also benefit from vitamin c and selenium together. Supposedly very magnesium deficient - but 2 years of supplementation doesnt seem to have done anyhting. The gains i have made with the b12 seem to have tapered off and though they have mainly held i am not going forwards anymore - sort of stuck (at one point i was hoping it would be a cure and that maybe i really 'just' had pernicious anemia or something but no such luck!) All the best, Justy.