Clearly for me - turning down that 'motor' that always seems to be running or the state of 'arousal' in my body is important for my health. But how to do that? I can think of some ways but I'm sure there are others: Amygdala Retraining Program Meditational type activities/Mindfulness Based Stress Reduction/Taking a Stand on Happiness , neurofeedback, breathing exercises Massage Reduced activity levels Klonopin Adaptogens (for some people) Anti-anxiety drugs It comes to mind that infections could trigger an ongoing immune response. Immune modulators could, I suppose, help too. I've heard that stimulants such as Provigil can actually calm some people down. Any other ideas? Aromatherapy?