The nature of paradoxical folate deficiency/insufficiency, donut hole type, appears to have a specific characteristic; the dose required to end insufficiency appears to keeps changing. Let’s look at how that happens. Let’s say a person starts with a 200mcg dose of Metafolin with sufficient MeCbl-AdoCbl to start healing. In about three days frequently occur low potassium and/or donut hole folate insufficiency as a set of symptoms often called “detox”. The folate insufficiency symptoms can be relieved by taking enough Metafolin. If a person titrates at 200mcg per day they likely will not resolve the symptoms. That is because the additional folate generates additional need and plenty of time to start even more healing. So the question comes up, what does it take to actually get out of Donut Hole Folate Insufficiency whether from Folinic Acid or l-methylfolate. IF a person starts at 200mcg and gets donut hole folate insufficiency started in 3 days THEN IF they drop to 100mcg the symptoms get worse or stay the same ELSE IF they raise by 200mcg daily increase once per week THEN the donut hole folate insufficiency stays about the same or may worsen. ELSE IF they raise the methylfolate dose to 800mcg to 1600mcg each dose (4-8x previous dose) THEN The folate insufficiency symptoms may reduce or go may away for some days to weeks or more until the amount of healing catches up to and exceeds the new dose available. Then insufficiency comes back. The key to stopping folate insufficiency is to get ahead of the healing that gets started. Often several doses of 4x the size of the current dose each 3 hours will generally make a noticeable difference in one day. Several successive doses of 8x as much will make a more definite difference quicker, often in one dose. Inflammation that takes weeks to get going doesn’t heal right away but will subside over a number of days of adequate dose and the difference can often be felt in hours. Methylfolate Bands of Sufficiency 1. 800mcg with no healing startup apparent, no donut hole insufficiency symptoms 2. 2400-4800mcg , healing startup with perhaps no folic or folinic or veggie folate difficulties and only donut hole insufficiency 3. 6000- 9000mcg, healing startup, some kind of relatively simple paradoxical folate insufficiency 4. 12,000- 24,000mcg, healing startup with moderate paradoxical folate deficiency 5. 28,000- 50,000mcg, healing startup, most severe paradoxical folate insufficiency These bands are determined pragmatically by the results people report. One of the things that has become very clear about l-methylfolate, is the seeming paradoxical effects. What one notices is the presence of deficiency or insuffiency symptoms. The results are symptoms that are inversely proportional to dose. The smaller the dose the more likely insufficiency symptoms are to be present as side effects, once at least one layer of healing is triggered. The larger the dose of L-methylfolate the less likely that folate insufficiency symptoms will appear. It appears that a person will have insufficiency symptoms all the way up to whatever their top of range is each time the dose goes up more slowly than healing increases.