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How to lower glutamate? Pharmacologics?

Discussion in 'Addressing Biotoxin, Chemical & Food Sensitivities' started by Thinktank, Jun 8, 2013.

  1. adreno

    adreno 3% neanderthal

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    Well, this is complex biochemistry, but the idea is that a high NAD/NADH ratio is what you want, not the other way around. Among other things this affects SIRT1 activation, which impacts longevity.
     
    Lotus97 likes this.
  2. Lotus97

    Lotus97 Senior Member

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    Since I'm sort of brainfogged (and might not understand it completely) and also because NAD is cheaper than NADH I'll just take your word for it then;)
     
  3. xchocoholic

    xchocoholic Senior Member

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    Fwiw, all chemicals depend on co-factors / catalysts to convert to other chemicals. So it's
    impossible to say x converts to y without acknowledging that this only happens if all
    co-factors are present. And yet I hear this all the time.

    We don't all have those enzymes or aminos available for converting x to y. Those of us with
    digestive problems may not have the aminos or enzymes needed. I need strong digestive
    enzymes just to get my food digested. Not all celiacs heal.

    Also, we need to keep in mind that the amounts of certain other chemicals in our bodies come into play here too.
    We all know that there's a chemical in grapefruit juice that interfers with the absorption
    of certain meds but what other chemicals do this ? Mercury ..

    Ok it's early and my brain just died, Lol, but do you see what I' trying to say. This person probably can't
    use supplements right now because his digestion is hosed.

    Tc ... X
     
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  4. Thinktank

    Thinktank Senior Member

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    I've taken zyrtec and loads of other antihistamines in the past for my pollen allergy but i can't tolerate it! Antihistamines make me very sleepy and numb but they do the trick allergy-wise. I have to say i do notice some benefits when on antihistamines like skin-improvement, a complete halt of my hair loss (alopecia androgenetica) and the irritated feeling in my eyes is less.
    Spring time / early summer in the Netherlands is HELL for me. I now live in Thailand and my pollen allergy has never popped up since being here.

    I took the antihistamines many years ago when i didn't have these serious gut problems yet. Maybe i should try zyrtec or any other next generation antihistamine just to see if it has any effect on my CFS symptoms. The mast-cell theory sounds interesting.

    I too have some kind of abnormality in the liver. It's called von Meyenburg complex which is basicly a formation of innumerable small cysts in the left and right lobe. I suspect this impairs my liver function like creating certain enzymes and especially blocking bile flow (which showed low on my CDSA).This all leading to accumulation of toxins and digestive issues etc.... But try to discuss that with a conventional doctor....

    NAC works well for me too but i get a bit anxious and stressed after a few days of using it.

    Have you tried nicotinamide? I read somewhere it's similar to nicotine.
     
  5. Thinktank

    Thinktank Senior Member

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    Yes i've tried digestive enzymes. One formula that gave me a few "clear" moments was NOW's super enzymes. Unfortunately i had to discontinue using it because i'm intollerant to some of the proteolitic enzymes. For a while i thought it was because of the betaine HCL in it, i tried supplementing betaine HCL but that caused a major gastritis flare.
    Creon helped me very well during my last flare but i fear it might make the inflammation worse if used longterm
    so I'm going to try enzymedica's gold enzymes soon.

    You've been most helpful :) Keep the info coming, one has to educate itself to improve.
     
  6. Thinktank

    Thinktank Senior Member

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  7. xchocoholic

    xchocoholic Senior Member

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    I haven't found mast cell problems to be the cause of my CFS but I certainly have a lot of allergies. I'm a celiac with leaky gut and multiple food and chemical intolerances, so the low histamine diet (which is recommended for those with mast cell problems) won't work for me. Then add kidney stones and pelvic pain and wallah, I'm on the low oxalate diet too. BTW, from what I've seen, my symptoms are common for those with leaky gut.

    H1 antihistamines knock me out too if I take the recommended dose. One 25 mg Vistaril put me in a semi coma for 3 days. I'm ok with 1/2 a Chidren's chewable or 1/2 - 1 tsp of the Dye free Liquid Benadryl during the day. I don't know why the liquid makes me sleepier than the chewable. Maybe it's because I allow the chewable to slowly disolve in my mouth so I'm not getting the full dose right away.

    Walgreen's brand zyrtec makes me less drowsy than the name brand. Taking 5mg at a time never makes me drowsy but 10 mg does. From what I've seen taking H2 allergy meds throughout the day is what mast cell specialists tell their patients. In fact some people are taking a lot more meds than I am. I've experimented with quite a few but settled on Wal-zyr. Allegra and Nasalcrom dry me out too much so I only take these during an allergy attack (non stop runny nose, etc).

    I take 10mg Wal-zyr at bedtime. If you're interested Walgreens has this med on their website but I'm not sure how the mail works where you are. I'd try taking a lesser dose more often of whatever you have first tho.

    Sorry to hear you have cysts in your liver. Do you have a doctor to discuss your CDSA with ? They'd probably know about liver enzymes. My freind with liver damage told me about the Himalaya liver care. I've been on it for several years now. I tried drinking warm lemon water in the morning but that only led to my teeth becoming sensitive.

    Nicotinamide is B3, right ? I didn't notice the same affects from nicotinamide as I do from nicotine. Sadly, the cig is working better than the lozenger too.
     
  8. xchocoholic

    xchocoholic Senior Member

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    I'm stuck with taking Creon for now and maybe forever. I'm 57 tho and my CDSAs are showing that I'm low on digestive enzymes. Creon is very expensive over here and luckily my insurance covers it but they wouldn't pay
    until I'd already tried the OTC enzymes. My dr just increased mine from 1 at meals to 2 and that's helped a great deal too.

    Why do you think these would make your inflamation worse ? They're just working on the food in your digestive tract. I understand why people who have these enzymes shouldn't use these but those who don't have these need to supplement. Or don't eat ... lol ...

    The Enzymedica Gold wasn't enough for me. If you look at Candidase and Virastop you'll see how high their protease count is. These didn't work as well as Creon is for me either tho. I only take these in addition to my creon if it feels like food is stuck in my digestive tract. These and Natural Calm keep food moving through me.

    Hope I didn't bore you with my digestive problems. I just thought if you've been on Creon you may be having similiar problems. tc ... x
     
  9. Living Dead

    Living Dead

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    Wikipedia says the GAPS diet contains bone broth. Broth is very high in glutamate. Also, meat and fish actually contains glutamate.

    This is kind of a not-confirmed thing, but if you don't have any other options you might have luck with a short corticosteroid course together with glutamine (without glutamine steroids just make you more leaky). Such as 40 mg methylprednisolone a day, halved every 20 days.
     
  10. Thinktank

    Thinktank Senior Member

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    I googled it but can't find any proof that bone broth is high in glutamate, just a few people mentioning it on forums.
    It guess the glutamate content of the broth will also depend on which type of meat / bone it's made from, chicken, beef, lamb etc.

    For me it is, i've experimented with an elimination diet and the IgG testing results were kinda spot on.
    Funny i tried 10mg prednisone yesterday just a few hours before your posting. I've low cortisol and high DHEA values. So i gave it a shot after reading it lowers DHEA and elevates cortisol. First 2 hours it gave me brain fog but after that i had high energy for the rest of the day.
     
  11. Thinktank

    Thinktank Senior Member

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    Ha, we have quite a bit in common. I also had kidney stones in the past. Being a male it was freaking painful to pass the stones!

    The cysts are "benign" as they say but i'm sure they cause complications for example blocking the bile flow.
    I have an appointment with a GI doc next week who seems to know a thing or two about the CDSA test.

    Yes nicotinamide is B3 and chemically close to nicotine, at least that's what i found out.
     
  12. Thinktank

    Thinktank Senior Member

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    There's a chance of fibrosing colonopathy. I experienced pain in the small bowel after a few weeks, the pain subsided a few days after i discontinued the use of creon. I believe high dose proteases can cause bowel irritation in some people.
    But when i was using the creon my stool looked much more digested and formed, i also gained a few kilo's which is very unusual for me. My latest CDSA shows i don't need to supplement digestive enzymes but i don't agree with that because the only thing i do seem to digest well is protein and certain carbohydrates. Fibrous stuff like most vegetables come out as whole lol.

    Good to hear the creon is working well for you. I rather go for a more functional approach and see supplementing with digestive enzymes as a temporary solution.

    Have you ever had an MRI of the upper abdomen? If you are low on digestive enzymes in the CDSA maybe you should have an MRI of your pancreas? Maybe test for lipase, amylase and protease in blood?
     
  13. xchocoholic

    xchocoholic Senior Member

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    Kidney stones too. Yikes. My condolensces. I get them everytime I try eating too many nuts. Been there
    Done that. Won't try it ever again. Lol. My last experience landed me in the er with pyleonephritis. Then
    I took a flouroquinolone that made my shoulders and knees go out. I'm still recovering.

    Candidase will break up the veggies for you. I'm not sure we want that tho. Our bodies
    don't naturally have cellulase. I see this in my stools too tho.

    I haven't had my pancreas looked at but I'm taking a break from finding new problems right
    now. If I went to a place like the Mayo Clinic right now, they'd have me seeing every specialist
    and I'd never get out. Lol.

    Have you looked at parasites, etc yet ?

    I started a parasite cleanse and metronidazole last week to see if it helps my digestion. I'm actually
    re-treating two serious infections I had last year dx via metametrix.

    Active b3 doesn't effect me at all from what I could tell. The effects from Nicotine are immediate.
     
  14. physicsstudent13

    physicsstudent13 Senior Member

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    so taking B3/B complex or methylfolate can help brain fog? my fog is returning it's terrible after I demasked on the ventilator and took a GABA/tryptophan supplement. maybe Alteril or glutamine isn't good and causes fog. IBS can cause fog also-I take bentyl for IBS once in a while
     

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