Ohh, that's just the top of obsurdity. No trials before more trials. If it wasn't so tragic, I'd laugh about it. There's a saying which goes "If an expert says it can't be done, get another expert". If you have some rheuma symptoms sandralee, perhaps he could give it to you on that indication? About funding (in general), many hospitals and professors have a pot they can use for purposes they see fit. If you're in a country where insurance doesn't pay, but the state does instead, chances are present the hospital could just dispence the drug free of charge, the doctor apply for ethics approval, and perhaps publish. In some cases the doctor could give the drug without any ethics approval as well, on account of considering it to be beneficial for the patient, when no other options are present. The main point, IMO, is not publication. The main point is being allowed to try if one wants to try.