Weeks ago, I induced an overmethylation state. It’s horrible. Panic attacks, anxiety and paranoia, brain fog and depression, I never had this before. I stayed in this HELL for 3 weeks, then I tried to use B3 to alleviate my symptoms and it really helped. Before this overmetylation state, I was able to tolerate 100mg/day niacin and feel the effects for the entire week. Now I used 50mg 2 days ago, 50mg yesterday and 100mg today. I’m recovering, but I’m feeling my “hunger” for niacin is just increasing! If I don’t use, bad symptoms start to appear. I don’t know what’s happening, because I’m feeling niacin is losing effectiveness. Is possible these methyl groups accumulated in my body? I heard Sam-e do that. I can’t even consider the fact niacin will lose the effectiveness, I can’t return to paranoia/depression/anxiety/brain fog, things I never had!