Thanks Marco. I am still of the opinion - relating to my own case history - that chronic illness and that repeated relapses caused by further viral infections from which I could not 'bounce back' together with functional relapses and remissions (not all of the same degree); are 'the' reason for any continued 'stress'. But I am of course well aware that some might say/have said 'You would say that wouldn't you?' Particularly perhaps as I was in their definition a 'yuppie'. I just happen to think that there is something fundamentally different about the stress caused by a 'fluctuating condition' and that caused by one that progressively deteriorates - and that it relates to acceptance or the ability to accept. Get those mice infected with a virus, stress them out, let them recover to a level below that which they were able to function at before; infect them again, recover to even less of a level; infect again... randomise the time between each infection and the extent of each 'relapse' and 'recovery' - keep that up for 13 years - and THEN let's see what's what I love these research studies. They leave more questions than answers and rarely relate to my world!