@Ninan, I thought I'd share that extra potassium has been quite helpful for me. I take a prescription time-release version of potassium chloride (generic version of Klor-Con) that has 10mEq potassium. That helps. And then on top of that I often mix up an oral rehydration drink (like a homemade version of unflavored Pedialyte) with salt, potassium, etc. A liter of that has 20 mEq potassium. So that's 30 mEq per day. I checked with my cardiologist and he seemed to think that 30 mEq was fine for me without extra monitoring. But like @Ema said I'm sure it's something to be careful about, so check with your doctor, but you might try something like that. It may be that your current potassium intake is just not enough when taking Florinef (fludrocortisone). Or it may be that fludrocortisone just doesn't work for you. It doesn't work for everyone. I know you said that you are home-bound/bed-bound but does your doctor monitor your electrolytes at all with blood tests? I thought that doctors would want to measure that at least once a year for anyone taking fludrocortisone? And perhaps the doctor should be even a bit more careful to measure it when there are rapid increases in dosage? For what it's worth, I went through a period of increasing fludrocortisone, and having the effect wear off, but it was over the course of several years. Finally, I changed to a combination of both midodrine and fludrocortisone. Right now I'm taking 0.05 mg of fludrocortisone (1/2 tablet), once per day, and 5 mg midodrine, 3 to 4 times a day. Since you said that you generally have quite low blood pressure then midodrine might be an option for you. (Or did you already try it? I may have missed that....) Good luck! I's so hard to figure out what combination of drugs and supplements will be helpful.