I was thinking about the difference between my sister and I. Hashimoto's disease seems to run in our family. My mom had it and we developed it within a few years of each other. She uses synthroid also, but her doctor told her to take lots of zinc, calcium (12 to 15 Tums a day) and Iodine. She does not have fibromyalgia or CFS. I do and it started about the time I started taking synthroid. I was reading about a calcium channel blocker they use to treat cholesterol today. It is called Amlodipine besylate. It turns out that many people who are taking Amlodipine are developing Fibromyalgia. If your calcium channel is blocked you cannot create Superoxide dismutase or Gluthione--two antioxidants that prevent free radical damage and oxidative stress within your body. Gluthione is actually an antioxidant within your cells Without it, your cells become inflammed and die quicker. Your body also needs zinc to produce superoxide dismutase. There are several studies a person can look up on google scholar that claim they have measured superoxide dismutase and gluthione levels in people with fibromyalgia and they are much lower than control groups. What if this whole time, some of us with Hashimoto's are sick because we do not have enough zinc or calcium? And, if we took these we could get better? I just ordered lots of zinc and calcium along with superoxide dismustase, gluthione, quercetin, Vitamin E and C (All antioxidants). I will let you know if it works.