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How many people have had their 1,25 Vitamin D tested? Debunking the Marshall Protocol

Discussion in 'General ME/CFS Discussion' started by Beyond, Dec 8, 2013.

  1. Msinnott

    Msinnott

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    I realize now that you can take super high doses of vit d but without calcium it isn't going to do as much. Its all based on feedback mechanisms if you are low in calcium and your body senses that its going to send out high levels of pth to raise your calcium levels into the normal range and your body is going to raise the active form of vitamin d 1,25 to compensate.
     
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  2. leokitten

    leokitten Senior Member

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    Like a few of you have stated, there are more simple explanations as to why one has low 25-OH D3 and high 1,25-di-OH D3 (calcitriol) and I don't think the Marshall Protocol stated causes for why this happens are correct for most people. It's likely just due to a lack of calcium and that's what you need to fix:

     
    Last edited by a moderator: Mar 30, 2015
  3. Beyond

    Beyond Juice Me Up, Scotty!!!

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    Good post, that makes more sense than the BS of Marshall.
     
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  4. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    I did a search for that article and it is here.

    It sounds plausible.

    A lot of us seem to be dairy-intolerant, but you can be assured that dairy products are by no means necessary for an adequate calcium intake. The following may be of interest (sorry about poor quality).

    upload_2014-3-21_11-9-4.png
     
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  5. redaxe

    redaxe Senior Member

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    The Marshall Protocol has been around for years now. If it was as effective as its claimed to be then why aren't we seeing the results?

    Also my vit d results from several months ago
    25-OH D: 81 nmol/L (51-140)
    1-25 D: 220 (65-175)
     
    MeSci likes this.
  6. Msinnott

    Msinnott

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    Has anyone started lowering there vitamin d? I was at 5000 for a month and decided to start going a little lower because I felt so much better after the intial herx of lowering vitamin d. I dropped down to 2000 and started taking bromelian. I have been herxing like crazy increased joint and muscle pain. Lymph nodes in neck and arm pits swollen been getting high fever first day of swollen nodes. I am now on day 5 and every day I seem to be getting a little more energy and less pain. I have this chronic pain for a long time.
     
  7. Leopardtail

    Leopardtail Senior Member

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    You asked if anybody here had low 25,Vit-D and low 1,25 Vit D. I do on both counts.

    The picture with inflammation is simple - the immune system uses Vitamin D hence it should be high during inflammation. Converting 25,VitD to 1,25 VitD requires ATP so in severe ME you may well have inflammation and low 1,5 form. Many do in fact have low vitamin D.

    A bare adult torso in warm climates produces 10,000IU of vitamin D / hour so supplementing 5,000IU or less is very unlikely to do harm. Worries about high Vitamin D were caused by extreme examples of overdosing.

    It's most worth trying if you never get outdoors, or if you get much worse in winter. I would consider it more risky if you had high 0,25 Vit D rather than normal.
     
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  8. leokitten

    leokitten Senior Member

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  9. cigana

    cigana Senior Member

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    I have high 1,25 Di-OH Vit D at 99.4 (20.0-75.0).
     
  10. amaru7

    amaru7 Senior Member

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    I don't think much of Marshall, he's not even a medical doctor and he is alone in his theories. Vitamin D has been researched extremely well and is never proven to do harm. To me the guru in Vitamin D is always Professor holick. He has been one of the foremost researchers in this and I like his lectures very much, because he's entertaining and informative at the same time
     
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  11. Msinnott

    Msinnott

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    Well since lowering my vitamin d my 25oh levels are now 60. When they were only 50 on 10,000 iui vit d. I also have been taking mk7. I am going to try dropping my vitamin d down 2500iui since it's summer time now. Sometimes more isn't always better. Who knew I needed less to get my levels up where they needed to be.
     
  12. Leopardtail

    Leopardtail Senior Member

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    I was reading in williams yesterday that Vitamin D goes up with hypothyroidism, seems kinda weird but c'est la vie
     
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  13. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    Which type of Vitamin D goes up? How does hypothyroidism affect the balance between the two types?
     
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  14. cigana

    cigana Senior Member

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    Had my thyroid hormones tested a few times (T4,T3, free T4, TSH, reverse T3), everything's fine. Also tried a course of T3.
     
  15. Leopardtail

    Leopardtail Senior Member

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    The text indicated that the conversion of 0,25 Vitamin D (storage form) to 1,25 Vitamin D (active form) was upregulated. It gave no indication of whether 0.25 Vitamin was replaced or lowered.
     
    Last edited: Jun 4, 2014
  16. roxie60

    roxie60 Senior Member

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    My recent D 25 OH hydroxy was 25. Has not been higher than 55. Never tested 1.25, just read about it last night. Found it interesting that Marshall listed patients with Lyme. This stuff is so complex. Glad there is another paper. Also a bit scarry one paper commented that the use of long term Bactrim (septra?) caused Lupus.
     
  17. roxie60

    roxie60 Senior Member

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    I wonder how our genes might impact our vit D levels in addition to infections and autoimmune issues
     
  18. Beyond

    Beyond Juice Me Up, Scotty!!!

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    I will probably try one last time supplementing vitamin D. Candidates are mycellized or Vitashine derived from lichen. Other attempts have proven to be highly placebolic despite very promising studies showing deep impact on sleep.
     
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  19. roxie60

    roxie60 Senior Member

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    I'm using g Ortho molecular VitD3 K2
     
  20. Beyond

    Beyond Juice Me Up, Scotty!!!

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    Thats a very expensive brand, should be high quality. However I have taken also professional level brands with no improvement at all. What I am expecting from D3 or any supplement really is some relief of symptoms, even if subtle. If you don´t feel better, why bother?
     

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