I've cut the dose from 15g/day to 5g/day because of cost (i'm looking into cheaper alternatives but prefer them to be from name brand companies). I've noticed the reduced energy and stamina, took a couple weeks though these have been rough weeks for me overdoing it plus other supplement changes so not a very clear cut cause/relationship finding. I am wondering if i need to do something how far in advance should i take an extra teaspoon to help get me through it, i've googled it but not come up with much except that when beginning Ribose therapy expect 2 weeks to see results (for heart failure). Also i've seen no evidence that one should divide doses at all except everyone says do it but no reference to it making any difference or where the recommendation comes from (except probably parroting where they got their ribose information). I know Dr Myhill says 3x a day but again where does that come from? I can't tell any difference but again i've burned myself so i can't really say Thanks for any insights.