Or when did you give up? I've been on Fredd's protocol for about a month, and am just not seeing any increase in energy. I'm taking most all the cofactos (except didn't do well with sam-e/tmg) and have avoided the confounding factors (folic acid, gulthathione). And have been on decently large doses (of all the right brands) of the 12's (6mg mb12 a day, 6mg adb12 a week, LOTS of methylfolate - in the range of 4800mcg a day) for several weeks (sorry for the vagueness, I don't have my notebook with me that I track this in and my memory is crud). My problem is that I seem to be tolerating most everything well now (had muscle cramping to start) but have had zero energy improvement. Just to be clear, I don't expect miraculous, dramatic or overnight results but I haven't had even a glimmer of energy improvement since starting this. And it seems like everyone else has some at least initial energy increase (and everyone has a nicer car/better hair, etc. ; ) Could it really be taking this long even for an even temporary energy improvement? Or is this just not working for me?