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How long before low dose naltrexone works?

Discussion in 'Alternative Therapies' started by LJBluesky, Sep 30, 2013.

  1. SOC

    SOC Moderator and Senior Member

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    There's NK cell number and NK cell function. Do you have both results? Maybe if you tell us, people can help you compare.

    ETA: Duh! See you gave it above and I missed it. I'll blame brain fog. ;)

    Your function looks in normal range, if I'm reading correctly. Are your numbers low?
  2. Clodomir

    Clodomir In hibernation mood

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    Hi,

    Happily, it takes me 2 month!

    Now i can't imagine living without!
    I am taking now IV ABX for lyme and i am herxing but it is manageable ( i think thanks to LDN)

    Have a nice day

    Clodomir
  3. Soundthealarm21

    Soundthealarm21 Senior Member

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    Mine specifically says NK Cell Function Assay. That's the only one that got done.

    Also, I'm talking to my doc on Tuesday and getting the LDN dose dropped. You all were right to recommend not starting high. It has indeed made me very sick. So I have to deal with that and a vit C IV herx at the same time. Not very comfortable! What is a good starting dose?

    Thanks!
  4. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    It seems individual. The average is about 1.5 mg but some need to start at .5 mg. Maybe get a form (I like liquid) where it is easy to change doses.

    Sushi
  5. madietodd

    madietodd Senior Member

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    I've taken 0.5mg for 4 nights now, with no good or bad effects. In case this IS doing something, and my body's adjusting, I'm going to stay at this dose for a week, and then start bumping up.
  6. Soundthealarm21

    Soundthealarm21 Senior Member

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    Okay, you all were right. I tried to tell my doc and he dropped it to three and I trusted him and I have had one of the worst days I've ever had.

    Is there such thing as withdrawal or is something else happening? I feel so ill. Does anyone know roughly how long it takes for the system to calm down?
  7. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Most people metabolize LDN pretty quickly and I think it has a short half life. Shouldn't be any withdrawal, but, that dose might have kicked your immune system in the ass and it could take a bit to calm down.

    Best,
    Sushi
  8. Yin

    Yin

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    I started LDN this month at .5 mg, then 1 mg, then 1.5 mg. It was wonderful for pain -- better than Tramadol -- and made me fairly alert. BUT, It made me feel very, very depressed and unable to handle stress at all. I was on Famvir, which already makes me depressed and emotional. HHV6, HSV1 and EBV keep my cortisol levels low. LDN seemed to make both worse. I was crying every day, feeling like I could not make decisions, like everything was too hard, and even a few days like I wanted to die. I stopped both LDN and Famvir 2 days ago and feel back to my normal self today.

    Should I go back on LDN but stay at .5 mg longer? I did not feel pain relief at .5, so went to 1.0 the next day, and then 1.5 2 days later.

    Or, does LDN lower cortisol, and so if you are dealing with viruses, it may not be right for you? thank you for any ideas! I was so looking forward to LDN being my answer, but I was miserable emotionally on it.
  9. CantThink

    CantThink

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    I took a long time to increase my dosages . I had a bad herx everytime I increased:

    Night sweats
    Mucus shifting
    Feeling bouts of extremely hot or flushed (despite it being actually very cold)
    Headache/Migraine the first night
    Extreme exhaustion
    Fitful sleep
    Lead weight feeling

    and the herx typically ended up going on for 5 to 7 days or so. I ended up having to increase when I knew I was able to be pretty much bedbound for the recovery period and after that I would feel back to my 'normal'.

    I kept/keep a blog about it. This is what I wrote:

    Despite knowing that LDN can promote initial herx reactions, I never expected to become completely and utterly incapacitated by it. I thought herx might mean headaches and nausea or something along those lines. This total crash is horrible, as on a normal, good day I usually get up for a bit and get something done, and spend then rest of the time up (as in dressed and downstairs), but either seated or lying down.

    I started on 0.75mg and 13 months later I am on 4mg. I have experienced benefits, but have definitely not had a straight and smooth course of improvements... I seem to have ups and downs so sometimes it feels as if it's not doing anything.

    As a result, I have tried to look at the overall picture, which shows improvement. This year I have done more than I have managed to do since 2009, so to me that is improvement. I should note here that I also have Auto Immune Thyroid Disease so some of the benefits may be related to that, as some people take it for that alone.

    It's hard to quantify, but I noticed overall that I have had an increase in my stamina, a decrease in feelings of apathy (which I developed - the apathy - once I developed the thyroid disease), and when I do manage to get a whole night of sleep, I seem to be sleeping deeper and getting dreams. Before taking it, I could feel I was not getting that deep sleep and I went for years without having any dreams (prior to that state I was having horrid psychedelic ones). I still struggle to actually get to sleep and have to practice sleep hygiene and turn off any wi-fi applicances that are nearish to my room or in my room or I have a terrible night of tossing and turning. Getting a night of sleep definitely makes a big difference!

    I think that it really helps to keep some form of record of symptoms/a journal/blog while taking LDN as it helps to measure improvements, if any. I think maybe 6 months to a year is a good amount of time to trial it before giving up.

    I accidentally missed 2 doses in the summer and I rued that! I quickly (because it has such a short life) relapsed - as it was obviously doing something!! - and it took me a while to get back to where I was before the missed doses.


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