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How likely is high vit. C a mast cell degranulator?

Discussion in 'Hypersensitivity and Intolerance' started by sillysocks84, Oct 14, 2015.

  1. sillysocks84

    sillysocks84 Senior Member

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    http://meandmymastcells.com/category/nutrition/vitamins/

    Well, i have been taking high doses of vitamin c for my mast cell problems because I know it is a mast cell stabilizer. Apparently in high amounts it becomes the opposite. Which may explain why my palms itch after taking high doses. This article says if you take 1g (1,000mg) split it throughout the day not all at once.

    *edited * I don't believe it's the vitamin c making my hands itch, but if it is it may be an additive.
     
    Last edited: Oct 14, 2015
  2. Gingergrrl

    Gingergrrl Senior Member

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    @sillysocks84 am not sure what to think about this b/c Vit C is supposed to be a mast cell stabilizer and there is 700 mg (approx) in the Quercetin that I take (2x a day in divided doses) and it seems to work well for me. It is pure Vit C without the additives in many other Vit C's. My MCAS doc wants me to keep taking it. Maybe each person reacts differently to Vit C?
     
  3. sillysocks84

    sillysocks84 Senior Member

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    That could be too! That we all react differently. I had never heard this before myself. So maybe someone can debunk this or explain it. But on the other hand I'm wondering why my hands itch when I take high c doses. I usually take 2,500 mg at a time or more. Maybe every body has it's own optimal level??
     
  4. Gingergrrl

    Gingergrrl Senior Member

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    Maybe it is just too high a dose? My total dose for the day is around 1420 mg (would have to check the Quercetin bottle but this is approx it.) I usually divide things into divided doses so nothing too high of an amount at once.
     
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  5. Ema

    Ema Senior Member

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    She doesn't provide a reference and also says that the concentrations of vitamin C to achieve mast cell degranulation are not achievable using standard supplements.

    The only reference I can find is that when Vit C is used to kill mast cell tumor cells, it can cause a massive release of histamine as those cells are destroyed. But this does not happen to normal, non cancerous cells.

    I'd take that blog with a grain of salt...
     
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  6. sillysocks84

    sillysocks84 Senior Member

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    Thank you @Ema I won't read anything elserious by her
     
  7. sillysocks84

    sillysocks84 Senior Member

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    And I'm deleting this thread
     
  8. Gingergrrl

    Gingergrrl Senior Member

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    I don't know if you can delete a thread and it also might be helpful for others to read. But you can change the title of the thread if you want to.
     
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  9. sillysocks84

    sillysocks84 Senior Member

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    Umm silly question, how do I delete this?
     
  10. sillysocks84

    sillysocks84 Senior Member

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    OK will do:)
     
  11. Sushi

    Sushi Senior Member Albuquerque

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    You can't delete a thread--only a moderator can. Also, there should be a good reason for deleting it.
     
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  12. Sushi

    Sushi Senior Member Albuquerque

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    Vitamin C has different biochemical actions at different dose levels. I don't know anything about dosing for possible help with MCAS, but for glutathione, here is a quick break down. Doses up to about 3000 mg will use glutathione to metabolize the C, doses in the mid-range have a neutral effect on glutathione, and at high (bowel tolerance) doses, the C is used to metabolize the glutathione. Hope I got that right! :)

    That is a synopsis from Dr. Rich Van Konynenburg who had references for it. So, in short, low doses of C may, to a mild extent, reduce glutathione levels, whereas high doses may, to a mild extent, increase them. If you can relate glutathione to MCAS, you might tease something out of that.
     
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  13. sillysocks84

    sillysocks84 Senior Member

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    @nanonug also said gluthathione was helping him at one point.

    Link:
    http://forums.phoenixrising.me/index.php?threads/a-new-glutathione-depletion-hypothesis.20301/

    So maybe we do need higher doses to metabolize the gluthathione better. Thanks for that information @Sushi
     
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  14. sillysocks84

    sillysocks84 Senior Member

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    So more and more, it looks like that blog I posted was way off quite possibly...
     
  15. Gingergrrl

    Gingergrrl Senior Member

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    @Sushi I am not sure if I am interpreting this correctly but do you mean that if I am taking less than 3000 mg of Vit C per day (I take approx 1500 mg per day) that I am using up needed glutathione to metabolize the C and this could be a bad thing overall?

    @sillysocks84 I need to re-read some of nanonug's posts and I don't think he is on PR anymore. I am trying glutathione by nebulizer next week and really hoping this will help me to lower the inflammation in my lungs and body. It is risky but am trying at hospital and for me at this point, it is worth the risk!
     
  16. sillysocks84

    sillysocks84 Senior Member

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    I noticed he wasn't here anymore either :-(. I wanted to ask him about this :
    But...I think it sounds like your doctor is putting you on the right track. It seems like maybe you needed more of glutathione. Higher c doses from what I understand, help you metabolize the gluthathione. Yours seem midrange so have a neutral effect most likely.
     
  17. Sushi

    Sushi Senior Member Albuquerque

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    Well, you induced to look up my sources and check my memory--I was too busy to do that before. Turns out I had it slightly wrong. The following is a conversation between Rich and a member of an immune support forum:

     
  18. Gingergrrl

    Gingergrrl Senior Member

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    I know, I would like to ask him, too! Maybe he is not around b/c he is well now?!! I cannot do stuff in IV form so will be nebulizing glutathione. If I tolerate it, I can easily increase the Vit C and will research this more.
     
  19. Gingergrrl

    Gingergrrl Senior Member

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    @Sushi, now am not sure if I understand it after all! Is Rich saying that the lower doses are actually better b/c they don't put a high demand on using your glutathione?
     
  20. Sushi

    Sushi Senior Member Albuquerque

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    What I understand from this (which could be wrong!) is that mid-range doses could deplete glutathione but that low would not effect glutathione levels and high might actually increase glutathione.
     
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