When I think of chronic pain I think mainly of hormone deficiencies. And any hormone deficiency can cause chronic pain. This is a great article. I have NEVER responded to any serotonin increasing drugs well. Yet my glutaminergic system is extremely hyperactive. Neuroresearchers are now discovering that the reason these SSRIs and Lithium and whatnot decrease depression is because they modify other factors in the brain like these and increase growth factors and resistance to stress. That is actually their main mechanism of action which is why you don't just take one and wake up a new person for a week. In any event SSRIs still put me to sleep and this sounds like something interesting to try. I personally think that in a lot of our cases our adrenaline/stress levels are so high due to low hormone levels and or hypovolemia. I know when I fix my hypovolemia my stress/adrenaline goes down almost completely.