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How have selection bias and disease misclassification undermined the validity of myalgic encephalomy

Discussion in 'Latest ME/CFS Research' started by AndyPR, Mar 10, 2017.

  1. AndyPR

    AndyPR Senior Member

    http://journals.sagepub.com/doi/full/10.1177/1359105317695803

    I did search but couldn't see this posted on PR yet.
     
    Aroa, slysaint, Esther12 and 19 others like this.
  2. ScottTriGuy

    ScottTriGuy Stop the harm. Start the research and treatment.

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    Toronto, Canada
  3. A.B.

    A.B. Senior Member

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    The effect seen in PACE is likely an artifact of poor methodology and post-hoc protocol changes, and is comparable in strength to a placebo (the placebo effect size is about 19% for psychological interventions in CFS according to a review by some CBT/GET proponents themselves). The transient nature of this effect and the lack of objective improvements show us that CBT/GET don't even work for a "chronic fatigue" sample. I suspect that a "chronic fatigue" sample is less at risk of GET induced deterioration though.

    This said, I think this is an outstanding article. Some of the confusion and uncertainty surrounding this illness is simply due to bad definitions.
     
    Valentijn, MEMum, Hutan and 6 others like this.
  4. charles shepherd

    charles shepherd Senior Member

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    This paper comes from the ME Biobank team at LSHTM and has been published in the Journal of Health Psychology - which seems to be adopting a helpful and constructive approach to the biomedical model of causation and management of ME/CFS

    There is more to come!

    CS
     
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  5. Barry53

    Barry53 Senior Member

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    [My italics/underline]
    A nice illustration of how the PACE trial epitomises "a little knowledge is dangerous thing" when the authors are effectively claiming to be the world's leading experts.
     
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