The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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how does LPS get processed in the body?

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by ebethc, Jan 28, 2018.

  1. ebethc

    ebethc Senior Member

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    does anyone know the pathways for LPS in the body? If I knew, maybe I could find a way to help my body get it out, like saunas or something. thanks.
     
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  2. Learner1

    Learner1 Professional Patient

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    I looked it up as I was curious. They seem to be eliminated through the liver. Apparently IVIG and monoclonal antibodies can help, too.

    How do you know if you have an issue with them?
     
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  3. ebethc

    ebethc Senior Member

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    if you have leaky gut, you have LPS in the bloodstream, correct? Is there a serum LPS test?
     
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  4. Learner1

    Learner1 Professional Patient

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  5. Thinktank

    Thinktank Senior Member

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    CD14 can be tested in blood. CD14 binds to LPS, so an increase in CD14 might indicate a hyperpermeable intestinal lining.
     
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  6. Learner1

    Learner1 Professional Patient

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    I was just listening to an interview with Dr. Bernarda Zenker. She dug into effects of LPS and found they can:

    1) unregulate IL6 and TNFalpha
    2) promote cytokine storms
    3) inhibit methylation
     
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  7. ebethc

    ebethc Senior Member

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    makes sense to me...

    did she have any suggestions for helping your body process it out..? I believe it's metabolized by the liver, which means that it would go back into your gut... I was thinking of getting back into the sauna and trying that route to take the burden off my liver detox pathways..

    cc @ljimbo423
     

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